TcruziDB, an Integrated Database, and the WWW Information Server for the Trypanosoma cruzi Genome Project

Abstract

Data analysis, presentation and distribution is of utmost importance to a genome project. A public domain software, ACeDB, has been chosen as the common basis for parasite genome databases, and a first release of TcruziDB, the Trypanosoma cruzi genome database, is available by ftp from ftp:// iris.dbbm.fiocruz.br/pub/genomedb/TcruziDB as well as versions of the software for different operating systems (ftp://iris.dbbm.fiocruz.br/pub/unixsoft/). Moreover, data originated from the project are available from the WWW server at http://www.dbbm.fiocruz.br. It contains biological and parasitological data on CL Brener, its karyotype, all available T. cruzi sequences from Genbank, data on the ESTsequencing project and on available libraries, a T. cruzi codon table and a listing of activities and participating groups in the genome project, as well as meeting reports. T. cruzi discussion lists (tcruzi

Creating innovation capabilities for improving global health: Inventing technology for neglected tropical diseases in Brazil

“…In Latin America, around 6 million people are infected, with 70 million at risk of infection (WHO, 2017 ). The T. Cruzi Genome Consortium was a north–south network involving 20 labs, including Brazilian universities and those from Argentina, Venezuela, England, Spain, and the USA, plus the Pasteur Institute in France and the WHO (Degrave, de Miranda, Alex, Brandão, Aslett, & Vandeyar, 1997 ). Until the 1990s, developing countries were left out of major genome projects when involvement is crucial for developing drugs, vaccines, and diagnostics.…”

Parasitic diseases: opportunities and challenges in the 21st century

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Chagas disease, from discovery to control - and beyond: history, myths and lessons to take home

“…The new biology -technology intensive and addressing complex problems -has to be carried out through networks and international collaboration, and will have to rely on the newest communication and information technology (Degrave et al 1997b). …”