Effects of Goyazensolide during in Vitro Cultivation of Schistosoma mansoni

Barth, L R; Fernandes, A P M; Ribeiro-Paes, João Tadeu; Rodrigues, Vanderlei

doi:10.1590/s0074-02761997000300022

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…A 90-100% mortality of Schistosoma worms was found affected in vitro by 4 mg=mL goyazensolide, a component extracted from Eremanthus goyazensis (Barth et al, 1997), and 200 mg l À1 of an ethyl acetate extract of ginger, Zingiber officinale (Sanderson et al, 2002). In vitro antischistosomal activity was possessed by robustic acid and an isoflavone compound isolated from the seeds of the tree Millettia thonningii (Lyddiard et al, 2002), as well as extracts of Scilla natalensis and Ledebouria ovatifolia (Sparg et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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In vitro bioassay screening of 346 methanol extracts originated from 281 native and cultivated plant species growing in Egypt, and related to 81 families, was carried out for schistosomicidal activity. The extracts were bioassayed at 100 mg=mL on viable Schistosoma mansoni mature worms in culture medium. Viability of worms was examined after exposure for 24 h, and mortality determined. Negative (DMSO) and positive (praziquantel) controls were used. Of the tested plant extracts, 72 were found to possess reproducible in vitro antischistosomal activity. These active extracts were further subjected to determination of their LC 50

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Section: Resultsmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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“…Also, goyazensolide, a natural compound isolated from the plant Eremanthus goyazensis, showed a significant inhibitory effect on egg laying of S. mansoni female worms during in vitro cultivation (Barth et al 1997). …”

Section: Discussionmentioning

confidence: 99%

Sativa seeds against Schistosoma mansoni different stages

Mohamed

Metwally

Mahmoud

2005

Mem. Inst. Oswaldo Cruz

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“…De Souza et al (1991) have found moderate reduction of worms in hamsters infected with S. mansoni after treatment with artemethen, a derivative of artemisinin. Barth et al (1997) found that in vitro tests on S. mansoni decreased motility of worms, inhibiting oviposition and high mortality of parasites when goyazensolide is used, a component extracted from Eremanthus goyazensis, a plant of the Asteraceae family.…”

Section: Medicinal Plantsmentioning

confidence: 99%

Medicinal plants and their bioactive constituents: A review of bioactivity against Schistosoma mansoni

Castro¹,

Mattos²,

Souza³

et al. 2013

J. Med. Plants Res.

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Schistosomiasis is a neglected disease that affects approximately 200 million people worldwide. In order to reduce the parasite prevalence, further researches aiming new treatment methods is necessary. Once infected by Shistossoma mansoni, one can have no symptoms in the acute phase, however, chronic phase is characterized by marked egg-induced hepatic granulomatous inflammation. To prevent the disease, the main prophylactic method is environmental sanitation which decreases the entrance of eggs into water bodies. In addition to fighting the snail, treatment of population is important. Currently, for treatment of schistosomisasis, the most used drugs are Praziquantel (PZQ) and Oxamniquine, whereas PZQ is the drug of choice. Each drug has a specific mechanism of action aimed at the elimination of the parasite. However, any parasite treatment based on the use of a single drug poses serious concerns regarding the onset of resistance. The search for new therapeutic agents derived from medicinal plants for schistosomiasis has progressed significantly in the last decade. The aim of this paper is to provide an updated survey on medicinal plants that have significant therapeutic effects in animal models of schistosomiasis. A considerable number of herbal constituents with schistosomicidal effect have been well characterized and may be good candidates for prospective studies and investigations that may result in clinical usage.

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Effects of Goyazensolide during in Vitro Cultivation of Schistosoma mansoni

Cited by 14 publications

References 9 publications

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Sativa seeds against Schistosoma mansoni different stages

Medicinal plants and their bioactive constituents: A review of bioactivity against Schistosoma mansoni

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