Laboratory indicators for monitoring HIV disease

Pereira, R. S.; Helbert, Matthew

doi:10.1590/s0074-02761996000300020

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…In addition to decimation of these cells, HIVmediated disruption of CD4 ? T cell functions also occurs thereby impacting on the classical pathways of immune function by altering the activation and production of specific effector T cells and immunoglobulins [12,19]. In HIVinfected, assessment of functional status of CD4 ?…”

Section: Introductionmentioning

confidence: 99%

“…In HIVinfected, assessment of functional status of CD4 ? T cells is good but this is said to be notoriously difficult as a laboratory routine [19]; hence, among others, the blood CD4 ? T cell count and HIV RNA copy number (plasma infectious HIV particles) have become major markers of AIDSdefining illnesses and response to clinical management of HIV and AIDS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CD4+ T Cell Response to Lamivudine, Stavudine and Nevirapine in Human Immunodeficiency Virus Infected Antiretroviral-Naive Men in Nigeria

Sule

Sani

2011

Indian J. Virol.

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Increase of (≥) 50 CD4(+) T cells/μl in post-commencement of highly active antiretroviral therapy (HAART) is acceptable as indicator of therapeutic success (TS). We therefore hypothesized that median change in CD4 count of the TS and therapeutic failure (TF) groups were comparable after 3 months; and that no associations existed between HAART outcome and adherence to therapy. One hundred Human immunodeficiency virus (HIV) infected antiretroviral (ARV) naive men on lamivudine + stavudine + nevirapine at Federal Medical Centre (FMC), Lokoja, Kogi State, Nigeria were studied. Data of the men were obtained with interviewer-administered questionnaire forms. Their ethylene diamine tetra acetic acid (EDTA)-treated whole blood samples were analysed with Partec CyFlow(®) Counter for pre-HAART and follow-up CD4 counts. Adherence to the ARV regimen was recorded for each patient as self-reported. We used Mann-Whitney U test, Kruskal-Wallis, Wilcoxon's matched pair and CHI(2) statistical tests for analyses. Overall adherence rate was 95.0%. Though the median follow-up CD4 count was higher (P = 0.001) than the pre-HAART value; only 85% of the men attained TS (increase of ≥50 cells/μl) at follow-up. Median change in CD4 count (+104.0 cells/μl; n = 85) of the TS was higher (P = 0.001) than that (-8.0 cells/μl; n = 15) of TF group; the two groups were however, comparable in age (P = 0.17) and body weight (P = 0.96). Only adherence and pre-HAART CD4 counts were associated (P = 0.001) with HAART outcome; while only age apparently influenced (P = 0.01) adherence rate. Eighty-five percent of the men benefited from the HAART. The success was apparently due to adherence and less than or (≤) 200 pre-HAART CD4 counts; while age ≥40 years appearently reduced adherence level.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%