1995
DOI: 10.1590/s0074-02761995000200030
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Abstract: The hypothesis that granuloma modulation and disease abatement in chronic infection with Schistosoma japonicum could be ascribed to antibody-mediated effects on egg maturation and egg viability, arose from studies performed with mice in the Philippines. This novel hypothesis has not yet been integrated into the schistosomiasis literature despite being formulated more than a decade ago. One reason for this is that the phenomenon might be confined to S. japonicum, even S. japonicum (Philippines).

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Cited by 3 publications
(3 citation statements)
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“…Two intriguing additional hypotheses explaining the decrease in the size of perioval granulomas are provided by the work of Mitchell et al (120,121). They noted that female S. japonicum miracidia induce a greater immunological response from mammalian hosts and that male eggs (and male worms) predominate in chronic infections.…”
Section: Role Of Schistosome Eggs In Development Of Diseasementioning
confidence: 99%
“…Two intriguing additional hypotheses explaining the decrease in the size of perioval granulomas are provided by the work of Mitchell et al (120,121). They noted that female S. japonicum miracidia induce a greater immunological response from mammalian hosts and that male eggs (and male worms) predominate in chronic infections.…”
Section: Role Of Schistosome Eggs In Development Of Diseasementioning
confidence: 99%
“…A major thrust of this collaborative research involved addressing diverse aspects of the host–parasite relationship and, in particular, to understand the phenomenon and implications of anti-embryonation immunity in schistosomiasis japonica. To do this, the Melbourne–Manila team undertook a number of experiments in mice that provided evidence to support their 1982 hypothesis [ 6 ] that granuloma modulation and a decline in chronic disease due to S. japonicum could be attributable to antibody-mediated effects on egg maturation and egg viability [ 7 , 8 , 9 , 10 , 11 ].…”
Section: Schistosomiasis Vaccine Research In Australia—the Beginningmentioning
confidence: 99%
“…An unexpected finding was that the maturation status of the egg influenced neither granuloma size at the early stage of infection at 9 wpi, nor the degree of modulation at the later stages. It has been shown that in murine schistosomiasis japonica, immature eggs are markedly less antigenic than mature ones, and that the granulomatous reaction is only small until the egg displays a miracidium (20,33). Kawanaka and Carter (34) reported that although excretory–secretory proteins were released from both immature and mature S. japonicum eggs, only proteins from mature eggs were reactive with human infected sera.…”
mentioning
confidence: 99%