The consequences of malaria infection in pregnant women and their infants

Chimsuku, L.; Verhoeff, Francine H.; Maxvell, S. M.; Broadhead, Robin L.; Thomas, Ann; Káay, H. J. Van Der; Russell, W. T.; Brabin, Bernard

doi:10.1590/s0074-02761994000600001

Cited by 8 publications

(4 citation statements)

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“…This may be due to the fact that pregnant women with malaria parasitaemia are likely to be anemic though may or may not be severe. This is in line with the report of Chimsuku et al 13 .…”

Section: Discussionsupporting

confidence: 94%

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2010

Biokemistri

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A seven month study (March-September 2006) on the prevalence of congenital malaria was carried out at the labour unit of three different hospitals within Ilorin metropolis: Eyitayo Hospital, Surulere Medical Hospital and Children Specialist Hospital Centre Gboro Ilorin. A total of 130 blood samples were collected from the mothers and their newborn babies and examined for malaria parasite using both thin and thick films. Maternal packed cell volume (PCV) and genotype was also determined using haematocrit method and cellulose acetate electrophoresis respectively. The prevalence rate of maternal, fetal, placental and cord parasitaemia were 37(28.46%), 29(22.31%), 33(25.38%) and 30(23.08%) respectively. Malaria infected maternal blood had a mild reduction in PCV level (p<0.05). Genotype showed strong correlation with maternal, fetal, placental and cord parasitaemia (p<0.05). However, the effect of malaria prophylaxis was shown to be more protective for the placental parasitaemia (p<0.05). Finally maternal age and parity did not show strong correlation with Maternal, fetal, placental and cord parasitaemia (p>0.05).

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“…This may be due to the fact that pregnant women with malaria parasitaemia are likely to be anemic though may or may not be severe. This is in line with the report of Chimsuku et al 13 .…”

Section: Discussionsupporting

confidence: 94%

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2010

Biokemistri

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“…This may be due to the fact that pregnant women with malaria parasitaemia are likely to be anemic though may or may not be severe. This is in line with Chimsuku et al, [1994] report.…”

Section: Congenital Malaria Is Defined As Malarial Parasites Demonstrsupporting

confidence: 93%

Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2009

Afr. Res. Rev.

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A total of 130 blood samples were collected from the mothers and their newborn babies and examined for malaria parasite using both thin and thick films. Maternal packed cell volume (PCV), and genotype was also determined using haematocrit method and cellulose acetate electrophoresis respectively. The prevalence rate of maternal, fetal, placental and cord parasitaemia were 37(28.46%), 29(22.31%), 33(25.38%) and 30(23.08%) respectively. Malaria infected maternal blood had a mild reduction in PCV level (p<0.05). Genotype showed strong correlation with maternal, fetal, placental and cord parasitaemia (p<0.05). However, the effect of malaria prophylaxis was shown to be more protective for the placental parasitaemia (p<0.

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“…In the present study, in a malaria-endemic area of western Kenya, mild-moderate anaemia was observed in 38.4% of the pregnant women investigated and severe anaemia was seen in 0.5%. These prevalences, although high compared with those seen in the developed world, are low compared with those reported in pregnant women by Chimsuku et al (1994) in Malawi (where 84.8% of the subjects had moderate anaemia) and by Bergsjø et al (1996) in Tanzania (where the prevalence of severe anaemia was 7%). It is unclear why anaemia was found to be rarer in the present study than among some other groups of pregnant African women but this observation may reflect different intensities of malarial infection, and/or different levels of micronutrient deficiency (especially iron deficiency) in the study populations (Yip, 2000).…”

Section: Discussionmentioning

confidence: 55%

Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya

Alusala

Estambale

Magnussen

et al. 2008

Annals of Tropical Medicine & Parasitology

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Between 2000 and 2004, a cross-sectional survey was conducted, as part of a prospective cohort study, among the women attending antenatal-care clinics in Bondo district, a malaria-endemic area of western Kenya. The aim was to assess the prevalence of iron deficiency and determine the predictors of haemoglobin and serum ferritin concentrations in the women who had a gestational age between 14 and 24 weeks. A standardized questionnaire was used to collect and store the relevant bio-data for the study. Haemoglobin and ferritin concentrations were evaluated, sickle-cell status was determined, and malarial parasitaemias were detected and evaluated, using blood samples collected at enrolment. Multiple regression analysis was then used to test for significant predictors of the haemoglobin and serum ferritin concentrations.Although 842 women were enrolled in the prospective cohort study, haemoglobin concentrations were evaluated for only 828 of them, serum ferritin levels for 621, and levels of parasitaemia for 812. The mean haemoglobin concentration recorded was 10.9 g/dl. Although 37.9% of the subjects had mild-moderate anaemia (7.0-10.5 g haemoglobin/dl), only 0.5% were severely anaemic (,7.0 g haemoglobin/dl). The geometric mean serum ferritin concentration recorded was 18.9 mg/litre, and 32.3% of the subjects evaluated had low serum concentrations of ferritin (,12 mg/litre). Among the parasitaemic primigravidae (but not the parasitaemic multigravidae), those found positive for sickle-cell trait had significantly lower haemoglobin concentrations than those found negative in a sickling test (P50.01). Among the pregnant women of Bondo district, gravidity, malarial infection and sickle cell appear to be key predictors of haemoglobin concentration.

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The consequences of malaria infection in pregnant women and their infants

Cited by 8 publications

References 0 publications

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Prevalence of Congenital Malaria in Ilorin, Nigeria

Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya

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