1992
DOI: 10.1590/s0074-02761992000800031
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Abstract: Severity of urinary tract morbidity increases with intensity and duration of Schistosoma haematobium infection. We assessed the ability of yearly drug therapy to control infection intensity and reduce S. haematobium-associated disease in children 5-21 years old in an endemic area of Kenya. In year 1, therapy resulted in reduced prevalence (66% to 22%, P < 0.001) and intensity of S. haematobium infection (20 to 2 eggs/10 mL urine), with corresponding reductions in the prevalence of hematuria (52% to 19%, P < 0.… Show more

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Cited by 33 publications
(27 citation statements)
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“…Structural urinary tract abnormalities detected by ultrasound were significantly improved after one year , and persistent abnormalities continued to improve in successive years (King et al 1992).…”
Section: Implementation Of School-based Control Began In 1984mentioning
confidence: 91%
“…Structural urinary tract abnormalities detected by ultrasound were significantly improved after one year , and persistent abnormalities continued to improve in successive years (King et al 1992).…”
Section: Implementation Of School-based Control Began In 1984mentioning
confidence: 91%
“…Hydronephrosis is found in 5% of residents, with peak prevalence of 10% among adolescents aged 12-15, with a second peak (6%) among subjects older than 49 yrs. It appears from longitudinal treatment studies that "acute" polypoid-granulomatous lesions, more common in younger individuals, are first to regress after therapy, and may disappear within weeks after treatment (King et al 1992, Hatz et al 1998. "Late" complications, such as hydronephrosis, may take a longer time (1-2 yrs) to show improvement, particularly in males (King et al 1992).…”
Section: Resultsmentioning
confidence: 99%
“…It appears from longitudinal treatment studies that "acute" polypoid-granulomatous lesions, more common in younger individuals, are first to regress after therapy, and may disappear within weeks after treatment (King et al 1992, Hatz et al 1998. "Late" complications, such as hydronephrosis, may take a longer time (1-2 yrs) to show improvement, particularly in males (King et al 1992). Elimination of infection does not terminate ongoing immune response to eggs trapped within tissues, and it is possible that fibrosis progresses for some time after successful cure of infection, and this may result in persistent dysfunction of the urinary tract.…”
Section: Resultsmentioning
confidence: 99%
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“…16,[29][30][31][32][33][34][35][36][37][38] However, these studies have been primarily focused on responses among children and not adults. Doehring and others documented improvement of bladder lesions associated with schistosomiasis among children within 2 months, 29 and found reversibility of urinary tract obstructive findings within 1 year after treatment.…”
Section: Discussionmentioning
confidence: 99%