1992
DOI: 10.1590/s0074-02761992000800002
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Abstract: The passive transfer of monoclonal antibodies, direct vaccination and in vitro assays have all shown that antigens associated with the tegumental membranes of Schistosoma mansoni are capable of mediating protective immune responses against the parasite in animal models. Furthermore, the principal antigens are highly antigenic during natural infection in man and stimulate strong humoral and cellular responses although, at present, their role in mediating protective immune responses in man remains equivocal. Thi… Show more

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Cited by 4 publications
(4 citation statements)
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“…Alternatively, absorption or uptake of host molecules or fragments thereof could have taken place that might explain the cross-reactivity within the tegument but not the embryos. [ 5 ]…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, absorption or uptake of host molecules or fragments thereof could have taken place that might explain the cross-reactivity within the tegument but not the embryos. [ 5 ]…”
Section: Discussionmentioning
confidence: 99%
“…In addition, antigenic posttranslational modifications could also alter antigen recognition properties of host immune system and thus, benefit the pathogen for their survival. Schistosome antigen proteins glycosylation could exactly illustrate this antigenic variation scheme [26,27] . In order to detect such antigenic variation events in schistosomes, we performed three types of analysis including site-specific selection variation, the combinations of different antigens and antigen modification.…”
Section: Schistosomes Escape Host Immune Surveillance Through Minor Smentioning
confidence: 91%
“…Glycosylation modification of the schistosome antigens, especially those of host blood group antigen origin, is one of the mechanisms of host immune evasion [26,27] . We had done the tegument proteins glycosylation modification analyses including glycosylation sites prediction using DictyOGlyc [30] and YinOYang (version 1.2) softwares and glycosylation patterns search analyses against Prosite database.…”
Section: Bioinformaticsmentioning
confidence: 99%
“…Thus damaged parasites may exude cytosolic material some of which will stick to the schistosome. Alternatively, it seems possible that the schistosome surface is adapted for the adsorption of soluble protein, perhaps as part of its strategy to acquire host antigens that act as an antigenic disguise (Simpson 1992), or on the contrary, may be the adsorption of soluble proteins of the parasite to the surface is relevant for stimulation of a strong protective immunity. Interestingly, there is a stricking accumulation of actin in areas of tegument recovering from damage (Matsumoto et al 1988).…”
Section: Soluble Proteinsmentioning
confidence: 99%