Phage typing of Micobacterium tuberculosis in Cuba

Misas, C. A. Jimenez; Alvares, J Ataliba; Zamora, D. Mazon

doi:10.1590/s0074-02761989000200019

Mem. Inst. Oswaldo Cruz

1989

DOI: 10.1590/s0074-02761989000200019

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Phage typing of Micobacterium tuberculosis in Cuba

C. A. Jimenez Misas

J Ataliba Alvares

D. Mazon Zamora

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2012

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“…A specialized phage can infect only a narrow range of hosts, so phage typing schemes are used in epidemiological studies of many bacterial pathogens, such as Staphylococcus aureus (2), Salmonella enterica serovar Typhimurium (3), Vibrio cholerae (4,5), and Mycobacterium tuberculosis (6)(7)(8). V. cholerae is the causative agent of the diarrheal disease cholera.…”

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confidence: 99%

O Antigen Is the Receptor of Vibrio cholerae Serogroup O1 El Tor Typing Phage VP4

Xu¹,

Zhang²,

Lü³

et al. 2012

Journal of Bacteriology

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Bacteriophage VP4 is a lytic phage of the Vibrio cholerae serogroup O1, and it is used in phage subtyping of V. cholerae biotype El Tor. Studies of phage infection mechanisms will promote the understanding of the basis of phage subtyping as well as the genetic differences between sensitive and resistant strains. In this study, we investigated the receptor that phage VP4 uses to bind to El Tor strains of V. cholerae and found that it infects strains through adsorbing the O antigen of V. cholerae O1. In some natural isolates that are resistant to VP4 infection, mutations were identified in the wb* cluster (O-antigen gene cluster), which is responsible for the biosynthesis of O antigen. Mutations in the manB, wbeE, and wbeU genes caused failure of adsorption of VP4 to these strains, whereas the observed amino acid residue mutations within wbeW and manC have no effect on VP4 infection. Additionally, although mutations in two resistant strains were found only in manB and wbeW, complementing both genes did not restore sensitivity to VP4 infection, suggesting that other resistance mechanisms may exist. Therefore, the mechanism of VP4 infection may provide a basis for subtyping the phage. Elaborate mutations of the O antigen may imbue V. cholerae strains with resistance to phage infection.

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confidence: 99%

O Antigen Is the Receptor of Vibrio cholerae Serogroup O1 El Tor Typing Phage VP4

Xu¹,

Zhang²,

Lü³

et al. 2012

Journal of Bacteriology

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Phage typing of Micobacterium tuberculosis in Cuba

Cited by 1 publication

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O Antigen Is the Receptor of Vibrio cholerae Serogroup O1 El Tor Typing Phage VP4

O Antigen Is the Receptor of Vibrio cholerae Serogroup O1 El Tor Typing Phage VP4

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