Virological study of a dengue type 1 epidemic at Rio de Janeiro

Nogueira, Rita Maria Ribeiro; Schatzmayr, Hermann G.; Miagostovich, Marize Pereira; Farias, Maria de Fátima D. B.; Filho, José da Costa Farias

doi:10.1590/s0074-02761988000200012

Cited by 50 publications

(25 citation statements)

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“…Recent (occurring in the previous two months) flavivirus infection was diagnosed for any individual with an IgM result Ͼ 40 U. [9][10][11] In most instances, these infections could be classified further as due to dengue virus or Japanese encephalitis virus, depending on the relative amounts of virus-specific IgM. A serological ratio of IgM antibody against dengue virus to IgM antibody against Japanese encephalitis virus Ͼ 1.1 defined dengue infection (DEN).…”

Section: Methodsmentioning

confidence: 99%

Distribution of dengue and Japanese encephalitis among children in rural and suburban Thai villages.

Strickman¹,

Sithiprasasna²,

Kittayapong³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. In the rainy season of 1989, IgG and IgM antibodies against dengue and Japanese encephalitis viruses (measured by enzyme-linked immunoassay [ELISA]) in serum from all primary-school children in two areas of central Thailand were sampled in order to choose a study site for more detailed epidemiological and entomological analysis. Students in three schools in the largely non-agricultural, suburban community of Bang Bua Thong, Nontaburi Province were sampled in late June and July. Of 1,477 children, 33/1,000 had recent dengue infection and 7/1,000 had recent JE infection. The rate of dengue infection in each village influenced the rate in schools, in that the rate of the school could be predicted from the proportion of students coming from each village. This result suggested that most transmission occurred in the residential environment; otherwise, the rate in each village going to a single school would be identical. Serum samples were taken in late August in the agricultural community of Hua Samrong, Chachoengsao Province. Of 748 students in two schools, 95/1,000 had signs of recent dengue infection and 32/1,000 had signs of recent JE infection. Two of 12 villages had significantly less flavivirus infection than some other villages and three villages had significantly more flavivirus infection. The children from one village had a dengue infection rate of 256 per 1,000, which was higher than the national average for the worst year (1987) previously recorded in Thailand. Within Hua Samrong, there was evidence for significant dengue transmission in one of the schools and concentrated transmission in small areas of two of the villages. The younger age group (3-8 years old) had significantly higher risk of infection by either flavivirus than older children. Elevated homes with wooden floors had significantly higher risk of dengue in the largest village. The observations from 1989 describe the epidemiological situation in rapidly developing, rural villages. This stage of development is probably being repeated throughout Southeast Asia as formerly isolated, rural villages become connected by transportation and economy to urban centers. What appears to be a single dengue outbreak based on passive surveillance conducted on a regional basis may actually be a variety of epidemiological situations. The practical implication of this conclusion is that application of a combination of vaccination and vector control should be targeted to higher risk areas in order to increase the likelihood of regional dengue virus eradication.

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Section: Methodsmentioning

confidence: 99%

Distribution of dengue and Japanese encephalitis among children in rural and suburban Thai villages.

Strickman¹,

Sithiprasasna²,

Kittayapong³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…89 In Brazil, an epidemic was reported in 1981-1982 in the state of Roraima, where DENV-1 and DENV-4 were identified. 90 In 1986 DENV-1 was introduced in Rio de Janeiro, Brazil, [91][92][93] spreading to other regions of the country. 94,95 The DENV-1 expanded and caused outbreaks in other countries that had been free of dengue for decades or had not experienced the disease before such as Bolivia (1987), Paraguay (1988), Ecuador (1988), and Peru (1990).…”

Section: Aedes Aegypti Reinfestation (1971-1999)mentioning

confidence: 99%

The History of Dengue Outbreaks in the Americas

Dick

Martín²,

Montoya³

et al. 2012

The American Society of Tropical Medicine and Hygiene

363

264

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Dengue is a viral disease usually transmitted by Aedes aegypti mosquitoes. Dengue outbreaks in the Americas reported in medical literature and to the Pan American Health Organization are described. The outbreak history from 1600 to 2010 was categorized into four phases: Introduction of dengue in the Americas (1600–1946); Continental plan for the eradication of the Ae. aegypti (1947–1970) marked by a successful eradication of the mosquito in 18 continental countries by 1962; Ae. aegypti reinfestation (1971–1999) caused by the failure of the mosquito eradication program; Increased dispersion of Ae. aegypti and dengue virus circulation (2000–2010) characterized by a marked increase in the number of outbreaks. During 2010 > 1.7 million dengue cases were reported, with 50,235 severe cases and 1,185 deaths. A dramatic increase in the number of outbreaks has been reported in recent years. Urgent global action is needed to avoid further disease spread.

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“…Successive epidemics have been reported in Rio de Janeiro, beginning in 1986 with the introduction of dengue virus serotype-1 (DENV-1) 6 . After an interval of four years, the city experienced an epidemic of dengue virus serotype-2 (DENV-2) from 1990-1991.…”

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confidence: 99%

Occurrence of severe dengue in Rio de Janeiro: an ecological study

Gibson

Souza-Santos

Siqueira

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:This study aimed to analyze the relationship between the incidence of severe dengue during the 2008 epidemic in Rio de Janeiro, Brazil, and socioeconomic indicators, as well as indicators of health service availability and previous circulation of the dengue virus serotype-3 (DENV-3). Methods: In this ecological study, the units of analysis were the districts of Rio de Janeiro. The data were incorporated into generalized linear models, and the incidence of severe dengue in each district was the outcome variable. Results: The districts with more cases of dengue fever in the 2001 epidemic and a higher percentage of residents who declared their skin color or race as black had higher incidence rates of severe dengue in the 2008 epidemic [incidence rate ratio (IRR)= 1.21; 95% confi dence interval ( 95% CI)= 1.05-1.40 and IRR= 1.34; 95% CI= 1.16-1.54, respectively]. In contrast, the districts with Family Health Strategy (FHS) clinics were more likely to have lower incidence rates of severe dengue in the 2008 epidemic (IRR= 0.81; 95% CI= 0.70-0.93). Conclusions: At the ecological level, our fi ndings suggest the persistence of health inequalities in this region of Brazil that are possibly due to greater social vulnerability among the selfdeclared black population. Additionally, the protective effect of FHS clinics may be due to the ease of access to other levels of care in the health system or to a reduced vulnerability to dengue transmission that is afforded by local practices to promote health.

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Virological study of a dengue type 1 epidemic at Rio de Janeiro

Cited by 50 publications

References 0 publications

Distribution of dengue and Japanese encephalitis among children in rural and suburban Thai villages.

Distribution of dengue and Japanese encephalitis among children in rural and suburban Thai villages.

The History of Dengue Outbreaks in the Americas

Occurrence of severe dengue in Rio de Janeiro: an ecological study

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