Colicinogeny in Salmonella serovars isolated in Brazil

Campos, Leila Carvalho; Hofer, Ernesto

doi:10.1590/s0074-02761988000200007

Cited by 4 publications

(2 citation statements)

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“…genomes for bacteriocin sequences that could be used by the pathogen to target host commensals during infection—we performed blast searches using E. coli colicins and microcins as query (File S1). Results confirmed the presence of ColB, ColE1, ColE2, ColIa, ColIb, ColM, and ColS4 in several S. enterica genomes (Table S1), as previously reported [148–150]. In addition, we identified ColE3‐E9, ColN, Col5, and Col10 (Table S1).…”

Section: Interbacterial Competition After the Induction Of Inflammationsupporting

confidence: 90%

“…Indeed, in vitro studies showed that some S. enterica strains are susceptible to E. coli colicins such as ColB, ColIa, ColIb, ColM, ColS4, Col5, and Col10 [130,146,147] (Table S1). At the same time, some S. enterica strains also produce colicins that affect E. coli , like ColB, ColE1, ColE2, ColIa, ColIb, ColK, ColM, and ColS4 [148–150] (Table S1). In addition to colicins homologous to E. coli , five colicin‐like proteins named salmocins were detected in several S. enterica serovars [130] (Table S1).…”

Section: Interbacterial Competition After the Induction Of Inflammationmentioning

confidence: 99%

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Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

et al. 2021

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A commensal microbial community is established in the mammalian gut during its development, and these organisms protect the host against pathogenic invaders. The hallmark of noninvasive Salmonella gut infection is the induction of inflammation via effector proteins secreted by the type III secretion system, which modulate host responses to create a new niche in which the pathogen can overcome the colonization resistance imposed by the microbiota. Several studies have shown that endogenous microbes are important to control Salmonella infection by competing for resources. However, there is limited information about antimicrobial mechanisms used by commensals and pathogens during these in vivo disputes for niche control. This review aims to revisit the steps that Salmonella needs to overcome during gut colonization—before and after the induction of inflammation—to achieve an effective infection. We focus on a series of reported and hypothetical antagonistic interbacterial interactions in which both contact‐independent and contact‐dependent mechanisms might define the outcome of the infection.

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Section: Interbacterial Competition After the Induction Of Inflammationsupporting

confidence: 90%

Section: Interbacterial Competition After the Induction Of Inflammationmentioning

confidence: 99%

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

et al. 2021

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Plant-made Salmonella bacteriocins salmocins for control of Salmonella pathovars

Schneider

Hahn-Löbmann

Stephan

et al. 2018

Sci Rep

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Salmonella enterica causes an estimated 1 million illnesses in the United States each year, resulting in 19,000 hospitalizations and 380 deaths, and is one of the four major global causes of diarrhoeal diseases. No effective treatments are available to the food industry. Much attention has been given to colicins, natural non-antibiotic proteins of the bacteriocin class, to control the related pathogen Escherichia coli. We searched Salmonella genomic databases for colicin analogues and cloned and expressed in plants five such proteins, which we call salmocins. Among those, SalE1a and SalE1b were found to possess broad antimicrobial activity against all 99 major Salmonella pathovars. Each of the two salmocins also showed remarkably high potency (>106 AU/µg recombinant protein, or >103 higher than colicins) against major pathogenic target strains. Treatment of poultry meat matrices contaminated with seven key pathogenic serovars confirmed salmocin efficacy as a food safety intervention against Salmonella.

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Selective Enrichment Media Bias the Types of Salmonella enterica Strains Isolated from Mixed Strain Cultures and Complex Enrichment Broths

Gorski

2012

PLoS ONE

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For foodborne outbreak investigations it can be difficult to isolate the relevant strain from food and/or environmental sources. If the sample is contaminated by more than one strain of the pathogen the relevant strain might be missed. In this study mixed cultures of Salmonella enterica were grown in one set of standard enrichment media to see if culture bias patterns emerged. Nineteen strains representing four serogroups and ten serotypes were compared in four-strain mixtures in Salmonella-only and in cattle fecal culture enrichment backgrounds using Salmonella enrichment media. One or more strain(s) emerged as dominant in each mixture. No serotype was most fit, but strains of serogroups C2 and E were more likely to dominate enrichment culture mixtures than strains of serogroups B or C1. Different versions of Rappaport-Vassiliadis (RV) medium gave different patterns of strain dominance in both Salmonella-only and fecal enrichment culture backgrounds. The fittest strains belonged to serogroups C1, C2, and E, and included strains of S. Infantis, S. Thompson S. Newport, S. 6,8:d:-, and S. Give. Strains of serogroup B, which included serotypes often seen in outbreaks such as S. Typhimurium, S. Saintpaul, and S. Schwarzengrund were less likely to emerge as dominant strains in the mixtures when using standard RV as part of the enrichment. Using a more nutrient-rich version of RV as part of the protocol led to a different pattern of strains emerging, however some were still present in very low numbers in the resulting population. These results indicate that outbreak investigations of food and/or other environmental samples should include multiple enrichment protocols to ensure isolation of target strains of Salmonella.

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Colicinogeny in Salmonella serovars isolated in Brazil

Cited by 4 publications

References 0 publications

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

Plant-made Salmonella bacteriocins salmocins for control of Salmonella pathovars

Selective Enrichment Media Bias the Types of Salmonella enterica Strains Isolated from Mixed Strain Cultures and Complex Enrichment Broths

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