Abdominal angiostrongyliasis: an under-diagnosed disease

Graeff-Teixeira, Carlos; Camillo-Coura, Léa; Lenzi, Henrique Leonel

doi:10.1590/s0074-02761987000800068

Cited by 19 publications

(13 citation statements)

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“…Despite high local seropositivity and infection prevalence in de®nitive (wild rodents) and intermediate (slugs) hosts (Duarte et al 1992;Morera 1995), the low incidence of reported and con®rmed clinical cases ± e.g., Costa Rica has only 21.6 cases per 100,000 inhabitants (Morera 1995) ± is attributed in part to the diculty of speci®cally diagnosing this zoonosis in humans. Furthermore, most human infections are thought to be subclinical, typi®ed by minor abdominal problems and spontaneous cure, depending on the number of larvae ingested and/or the individual immune response to the parasite (Grae-Teixeira et al 1987).…”

Section: Introductionmentioning

confidence: 99%

Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low-dose infection

Geiger

Graeff-Teixeira

Soboslay

et al. 1999

Parasitology Research

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Immunoglobulin isotype responses and parasite-specific antigen recognition were investigated in experimental Angiostrongylus costaricensis infection in two different mouse strains. Even in a low-dose infection with third-stage larvae (L3), BALB/c mice showed high mortality until 28 days postinfection (p.i.) in association with a low patency rate in surviving animals. On the other hand, low mortality and a high rate of patent infection was observed in C57BL/10 mice. Parasite-specific IgM, total IgG, and IgG subclasses against crude adult-worm antigen (AcAg) rose in both groups of mice from day 14 onward, with IgG and IgG1 being significantly elevated in BALB/c mice at 21 and 28 days p.i., respectively. For total IgE, significantly elevated concentrations were detected at 14 days p.i. in BALB/c mice as compared with C57BL/10 mice. A. costaricensis-specific antigen recognition by total IgG, IgG1, or IgG2a was similar in both mouse strains, intensifying from 3 to 4 weeks p.i., with recognition of immunodominant AcAg ranging between 80 and 210 kDa. This study provides evidence that in BALB/c and C57BL/10 mice, immunoglobulins, with the possible exception of IgE and IgG1, do not decisively contribute to the outcome of a primary A. costaricensis infection with respect to immunopathogenesis or parasite permissiveness.

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Section: Introductionmentioning

confidence: 99%

Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low-dose infection

Geiger

Graeff-Teixeira

Soboslay

et al. 1999

Parasitology Research

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“…Longitudinal studies have not yet been performed due to the limitations of diagnostic tests and the inefficacy of antiparasitic drugs. In conclusion, abdominal angiostrongyliasis is clearly an underdiagnosed disease [25]. Better knowledge about the distribution of this human infection will depend on awareness of the Fig.…”

Section: Introductionmentioning

confidence: 97%

“…disease among medical personnel, on epidemiologic surveys of the infection in regional mollusk populations and on reliable serological tests based on well-defined antigens that are still not available [22][23][24][25][26][27][28]. Pathologists should be on constant alert during histopathological analysis of cecal appendix and intestinal segments with intense eosinophilia; a detailed analysis can sometimes reveal eggs, vasculitis and even adult worms in unexpected material [29].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive proteomic profiling of adult Angiostrongylus costaricensis, a human parasitic nematode

Rebello

Barros

Mota

et al. 2011

Journal of Proteomics

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Angiostrongylus costaricensis is a nematode helminth that causes an intestinal acute inflammatory process known as abdominal angiostrongyliasis, which is a poorly understood human disease occurring in Latin America. Our aim was to study the proteomic profiles of adult parasites focusing on immunogenic proteins. Total cellular extracts from both genders showed similar 2-DE profiles, with 60% of all protein spots focused between pH 5-7 and presenting molecular masses from 20.1 to 66 kDa. A total of 53 different dominant proteins were identified in our dataset and were mainly associated with the following over-represented Gene Ontology Biological Process terms: "macromolecule metabolic process", "developmental process", "response to stress", and "biological regulation". Female and male immunoblots showed similar patterns of reactive proteins. Immunoreactive spots identified by MALDI-PSD were found to represent heat shock proteins, a putative abnormal DAuer Formation family member, and galectins. To date, very few biochemical analyses have focused on the nematode Angiostrongylus costaricensis. As such, our results contribute to a better understanding of its biology and the mechanisms underlying the host-parasite relationship associated with this species. Moreover, our findings represent a first step in the search for candidate proteins for diagnostic assays and the treatment of this parasitic infection.

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“…It is a sporadic disease, occurring mainly in the south of Brazil and other Latin America countries, particularly in Costa Rica 2 . However, the disease seems to be under diagnosed by the lack of suspicion when a patient presents with abdominal pain and eosinophilia 4 .…”

Section: Introductionmentioning

confidence: 99%

Abdominal angiostrongyliasis: report of two cases with different clinical presentations

Rodriguez

Dequi

Peruzzo

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAbdominal angiostrongyliasis is a sporadic infectious disease caused by the nematode Angiostrongylus costaricensis. It usually presents as acute abdomen, secondary to mesenteric ischemia, and pronounced eosinophilia. In some cases its course is insidious and transient, and the diagnosis is suspicious. The disease is confirmed by the detection of A. costaricensis elements in surgical specimen. The treatment is supportive, with avoidance of antihelminthic administration due to a possible erratic migration followed by worsening of the disease. We report two cases, both with intense eosinophilia and serum IgG-ELISA positive to A. costaricensis. The first case presented ileal perforation and was surgically treated. The second one showed hepatic nodules at ultrasound and was only symptomatically treated, evolving to an apparent protracted resolution. These two cases exemplify different clinical forms of the disease, one of them with liver involvement.

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Abdominal angiostrongyliasis: an under-diagnosed disease

Cited by 19 publications

References 0 publications

Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low-dose infection

Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low-dose infection

Comprehensive proteomic profiling of adult Angiostrongylus costaricensis, a human parasitic nematode

Abdominal angiostrongyliasis: report of two cases with different clinical presentations

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