Morbidade da doença de Chagas. II. Estudos seccionais em quatro áreas de campo no Brasil

Coura, José Rodrigues; Abreu, Laércio Luiz de; Dubois, Luc E. G.; Lima, Fernando Correia; Júnior, Evanízio de Arruda; Willcox, Henry P. F.; Anunziato, Ney; Petana, Walter B.

doi:10.1590/s0074-02761984000100012

Cited by 40 publications

(19 citation statements)

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“…However, lower morbidity rates are observed in other endemic regions of Latin America (40) (41) . In the present study, cardiomegaly was exclusively present with the cardiac and cardiodigestive forms,which is in agreement with previously reported data (42) (43) . However, the low sensitivity of chest radiography for identifying cardiac involvement is related to the right ventricle being one of the cardiac chambers that is most affected by CCC (44) .…”

Section: Discussionsupporting

confidence: 94%

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Andrade

Câmara

Nunes

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Section: Discussionsupporting

confidence: 94%

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Andrade

Câmara

Nunes

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…40 This same situation seems to occur with PCR performed in blood, where positive results in different chagasic populations and techniques fluctuate 45-100%. [20][21][22]41,42 The simultaneous application of 2 parasitologic tests increases diagnostic sensitivity, 43,44 but PCR is more sensitive in detecting circulating parasites.…”

Section: Discussionmentioning

confidence: 86%

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Lages‐Silva

Crema²,

Ramı́rez³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. The persistence of Trypanosoma cruzi in tissue and blood of 52 patients in the digestive form of chronic Chagas disease was studied. These patients had chagasic megaesophagus and underwent corrective surgery. Parasitologic (xenodiagnosis, hemoculture, or both), histopathologic (hematoxylin and eosin, and peroxidase-anti-peroxidase staining), and molecular (polymerase chain reaction [PCR] followed by slot-blot hybridization) tests were used in the analysis. The presence of T. cruzi, its genomic fragments, or its antigens could be detected in 98% (51 of 52) of the patients. The parasite was randomly identified in 76.9% of esophageal tissues and in 90.4% by PCR and in 73.1% by parasitologic methods from the blood. Fifty percent (26 of 52) of tissue samples had inflammation, 80.8% of which was associated with the parasite. Trypanosoma cruzi was also identified unassociated with inflammatory alterations. Higher tissue parasitism and intense inflammatory processes were observed in esophageal tissue from patients with Grade IV megaesophagus. These data demonstrate that in the digestive form of Chagas' disease, particularly in cases of megaesophagus, T. cruzi is frequently found, both in blood and tissues and may contribute to the pathogenic mechanisms involved.

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“…O confronto desses dados com os de outros trabalhos mostra que este percentual de positividade dos xenodiagnósticos não difere dos percentuais encontrados em áreas endêmicas de Minas Gerais 15 , apesar das diferenças em relação à metodologia como espécies empregadas e o modo de leitura das ninfas. Todavia, o percentual é significativamente maior do que os 13% encontrados em chagásicos de áreas endêmicas do Sertão da Paraíba 7 e significativamente menor do que os 36% encontrados por Castro 12 entre os chagásicos de Mambaí-GO.…”

Section: Discussionunclassified

Aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas em Mato Grosso do Sul

Pompílio

Dorval

Cunha

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMOCom o objetivo de avaliar aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas crônica, em pacientes do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, realizamos um estudo seccional envolvendo 120 chagásicos e 120 controles não-chagásicos, de ambos os sexos, com idades de 16 a 82 anos. Os aspectos epidemiológicos foram avaliados por questionário, a cardiopatia por exame clínico, eletrocardiograma convencional, radiologia e ecodopplercardiograma e a presença de Trypanosoma cruzi no sangue por xenodiagnóstico e teste da reação em cadeia da polimerase. Os resultados mostraram predominância de alóctones com baixa escolaridade e referência de contato prévio com triatomíneos entre os chagásicos. Abortamento espontâneo foi mais freqüente nas mulheres chagásicas. A cardiopatia devido ao componente chagásico foi estimada em 20,2%. Apresentou-se com 7,5% de cardiomegalia, 6,2% de aneurisma de ventrículo esquerdo e com predominância de dispnéia, palpitações e hipertensão arterial. O xenodiagnóstico foi positivo em 26,1% dos chagásicos enquanto a PCR foi positiva em 53,7%. A análise dos resultados indicou que a doença de Chagas no grupo estudado apresenta características clínicas e parasitológicas que revelam peculiaridades regionais. Palavras-chaves: Doença de Chagas. Estudo transversal. Aspectos parasitológicos. Aspectos clínicos. ABSTRACTWith the objective of evaluating epidemiologic, clinical and parasitologic aspects of chronic Chagas' disease in patients from the University Hospital of the Federal University of Mato Grosso do Sul, a cross-sectional study was performed with groups of 120 chagasic and non-chagasic patients aged from 16 to 82 years. Epidemiologic aspects were evaluated by means of a questionnaire, cardiopathy by clinical examination, conventional electrocardiogram, radiology and Doppler echocardiograms (only in chagasic patients) and the presence of Trypanosoma cruzi in the blood stream by way of xenodiagnosis and polymerase chain reaction test. The results obtained indicated that the chagasic patients are predominantly alloctones with low-grade schooling, and were exposed to triatomines. The frequency of spontaneous abortion was higher in chagasic women. Chronic chagasic cardiopathy, estimated to occur in 20.2% of the patients, showed 7.5% cardiomegaly, 6.2% aneurysm of the left ventricle, and with a predominance of dyspnea, palpitations and arterial hypertension. Xenodiagnosis was positive for 26.1% of the chagasics and the PCR was positive for 53.7%, and was significantly higher in males and alloctones. An analysis of the results shows that Chagas' disease, in the group studied, presented clinical and parasitologic characteristics demonstrating significant regional differences.

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Morbidade da doença de Chagas. II. Estudos seccionais em quatro áreas de campo no Brasil

Cited by 40 publications

References 0 publications

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Aspectos epidemiológicos, clínicos e parasitológicos da doença de Chagas em Mato Grosso do Sul

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