1982
DOI: 10.1590/s0074-02761982000300003
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Abstract: Foram estudados 17 indivíduos cujas idades variaram de 2 a 78 anos, procedentes da área endêmica de Jacarepaguá (RJ), com diagnóstico clínico, epidemiológico, imunológico e parasitológico de leishmaniose tegumentar americana. Todos foram tratados pelo antimoniato de N-metilglucamina na dose de 60 mg/kg/dia em três séries de 10 dias de duração, com 10 dias de intervalo entre cada série e submetidos à coleta e sangue venoso para a reação de imunofluorescência indireta (IF-IgG) antes, durante e após o medicamento… Show more

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Cited by 13 publications
(9 citation statements)
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“…Investigators generally describe a good correlation between cure of lesions and negative conversion of antibody titers detectable by IIF. 30,31 Based on these results, it has been suggested that negative conversion of IIF titers should be included as one of the criteria for cure. 31 Positive serology was reported in cured nonrelapsing patients, 17,32 but other investigators believe that a persistent positivity after treatment or spontaneous healing should be attributed to parasite persistence.…”
Section: Discussionmentioning
confidence: 99%
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“…Investigators generally describe a good correlation between cure of lesions and negative conversion of antibody titers detectable by IIF. 30,31 Based on these results, it has been suggested that negative conversion of IIF titers should be included as one of the criteria for cure. 31 Positive serology was reported in cured nonrelapsing patients, 17,32 but other investigators believe that a persistent positivity after treatment or spontaneous healing should be attributed to parasite persistence.…”
Section: Discussionmentioning
confidence: 99%
“…30,31 Based on these results, it has been suggested that negative conversion of IIF titers should be included as one of the criteria for cure. 31 Positive serology was reported in cured nonrelapsing patients, 17,32 but other investigators believe that a persistent positivity after treatment or spontaneous healing should be attributed to parasite persistence. 30,31 Such patients would be at risk for mucosal disease or cutaneous relapse.…”
Section: Discussionmentioning
confidence: 99%
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“…Antibody titers ≥ 1:45 were considered positive. The fluorescence was evaluated with an epifluorescence microscope (AxiophotZeiss, Germany) (Souza et al 1982).…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, the mucosal form may occur among these patients, generally appearing months or even years after the resolution of the skin lesions. Antibodies detected by indirect immunofluorescence assay (IFA) are negative after successful treatment of the disease (Furtado, 1980;Souza et al, 1982). The presence of anti-Leishmania antibodies after treatment may signify the persistence of the parasite, and the reduction of antibody titers has been suggested as a tool for the control of treatment efficacy (Chiari, Mayrink, Magalhães, 1973;Mendonça et al, 1988).…”
Section: Introductionmentioning
confidence: 99%