Tratamento pós-menopausa reduz a atividade da catalase e atenua o risco cardiovascular

Castanho, Vera Sylvia; Nakamura, Rui; Pinto‐Neto, Aarão Mendes; Faria, Eliana Cotta de

doi:10.1590/s0066-782x2012005000097

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…Ressalta-se que as mulheres idosas apresentaram maior prevalência de desenvolver fatores de risco cardiovascular tradicionais, como hipertensão, dislipidemia e diabetes 21 e, atrelado a isso, a questão hormonal é um fator a mais. Na menopausa ocorre a diminuição da produção de estrógeno, hormônio cardioprotetor, o qual apresenta atividade antioxidante e antiaterosclerótica 22 . Isso deve ser considerado válido para o manejo destas pacientes, uma vez que as doenças cardiovasculares constituem a principal causa de mortalidade entre a população de meia-idade 23 e a maior parte das mulheres atendidas pelo HIPERDIA da UBS estudada apresenta-se na pós-menopausa.…”

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Indicadores Antropométricos E Hábitos De Vida: Sucessão De Fatores De Risco Cardiovascular, No Interior Da Amazônia / Anthropometric Indicators and Life Habits: Succession of Cardiovascular Risk Factors, Inside the Amazon

Pantoja

Liberal

Costa³

et al. 2020

BJD

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As doenças cardiovasculares são uma das principais causas de morte entre os brasileiros. A associação de dois ou mais fatores de risco aumenta a probabilidade de desenvolver tais doenças, como em pacientes hipertensos e/ou diabéticos atendidos pelo programa HIPERDIA. Neste sentido, buscou-se elucidar os fatores de risco apresentados por pacientes atendidos pelo HIPERDIA em uma Unidade Básica de Saúde, considerando o perfil nutricional. Foi realizado um estudo descritivo com delineamento transversal, com a participação de 56 voluntários, sendo 11 homens e 45

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Section: Discussionunclassified

Indicadores Antropométricos E Hábitos De Vida: Sucessão De Fatores De Risco Cardiovascular, No Interior Da Amazônia / Anthropometric Indicators and Life Habits: Succession of Cardiovascular Risk Factors, Inside the Amazon

Pantoja

Liberal

Costa³

et al. 2020

BJD

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Síndrome metabólico y riesgo cardiovascular en mujeres posmenopáusicas de una institución de primer nivel de Envigado (Colombia)

Ángel

Valle

Ceballos

et al. 2014

Clínica e Investigación en Ginecología y Obstetricia

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Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

Liu¹,

Guo²,

Ma³

et al. 2015

Cell Physiol Biochem

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Aims: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17ß-estradiol and it can bind to the estrogen receptor. Here, we hypothesized that Tanshinone IIA might have anti-inflammatory and anti-oxidative effects in atherosclerosis, mediated through estrogen receptor activation. Methods: Subjects for this study were 120 apoE^-/- female mice and 20 C57/BL female mice. The apoE^-/- mice were ovariectomized (OVX) and the C57/BL mice were sham ovariectomized. The sham OVX mice were maintained on a normal diet (NOR) group. The OVX apoE^-/- mice were fed a high fat diet and randomly divided into 6 groups: Model (MOD) group which was fed a high fat diet only, E₂ group were given estrogen (E₂) 0.13mg/kg/d; E₂+ICI group were given E₂:0.13mg/kg/d and ICI182780:65mg/kg/m; TLD group (TanIIA low dose) were given TanIIA: 30mg/kg/d; THD group (TanIIA high dose) were given TanIIA:60mg/kg/d; and TLD+ICI group were given TanIIA 30mg/kg/d and ICI182780 65mg/kg/m. After three months of treatment, the aorta and the blood of the mice from each group was collected. The aorta were used for testing the lipid deposition by using hematoxylin and eosin(HE) and oil red O staining and for testing the expression of p-ERK1/2 by Western blot. The blood was used for testing the serum cholesterol, superoxide dismutase (SOD), methane dicarboxylic aldehyde (MDA), nuclear factor kappa (NF-κB), soluble intercellular cell adhesion molecule-1 (sICAM-1), activating protein-1 (AP-1), E-selectin and 17ß-estradiol in serum. Results: Tanshinone IIA significantly reduced the lipid deposition in aorta, decreased the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), MDA, NF-κB, sICAM-1, AP-1, and E-selectin in serum but increased the levels of high density lipoprotein (HDL) and SOD in serum. Tanshinone IIA also suppressed the expression of p-ERK1/2. Tanshinone IIA had no effect of level of serum 17ß-estradiol levels. All of the effects of Tanshinone IIA were similar to estrogen and were inhibited by the estrogen receptor antagonist ICI182780. Conclusion: Tanshinone IIA may play an anti-inflammatory and anti-oxidative stress role in OVX atherosclerotic apoE^-/- mice by activating the estrogen receptor through the ERK signaling pathway. Therefore, Tanshinone IIA, as a phytoestrogen, could be used for estrogen replacement therapy for cardiovascular disease of postmenopausal women.

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Tratamento pós-menopausa reduz a atividade da catalase e atenua o risco cardiovascular

Abstract: Background: Menopause can lead to alterations in women's health, with changes in the oxidative status of postmenopausal women in whom information regarding the influence of hormone therapy (HT) on antioxidant enzyme activities is limited.

Cited by 6 publications

References 38 publications

Indicadores Antropométricos E Hábitos De Vida: Sucessão De Fatores De Risco Cardiovascular, No Interior Da Amazônia / Anthropometric Indicators and Life Habits: Succession of Cardiovascular Risk Factors, Inside the Amazon

Indicadores Antropométricos E Hábitos De Vida: Sucessão De Fatores De Risco Cardiovascular, No Interior Da Amazônia / Anthropometric Indicators and Life Habits: Succession of Cardiovascular Risk Factors, Inside the Amazon

Síndrome metabólico y riesgo cardiovascular en mujeres posmenopáusicas de una institución de primer nivel de Envigado (Colombia)

Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

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