Redução da densidade de extrassístoles e dos sintomas relacionados após administração de magnésio por via oral

Falco, Cristina Nádja M. Lima De; Grupi, César José; Sosa, Eduardo; Scanavacca, Maurício; Hachul, Denise Tessariol; Lara, Sissy; Sacilotto, Luciana; Ramires, José Antônio Franchini; Darrieux, Francisco Carlos da Costa

doi:10.1590/s0066-782x2012005000043

Cited by 11 publications

(8 citation statements)

References 23 publications

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“…Patients with structural heart disease and the need for interventional procedures are often subject to toxic antiarrhythmic drug dosage and scarcely studied drug combinations [10] . ICD batteries are frequently depleted earlier than expected due to shocks that might be avoided, causing intense emotional and physical extenuation.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Ventricular Arrhythmia in Tetralogy of Fallot Repair Using Catheter Ablation

Valdigem¹,

Moreira²,

Andalaft³

et al. 2018

Braz J Cardiovasc Surg

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Tetralogy of Fallot (ToF) is one of the most prevalent congenital heart disease. Its surgical corrections may haemodinamically correct a disease, but the incisions may create scars that will originate ventricular arrhythmias. Even though life threatening arrhythmias are not common, some patients present unstable ventricular tachycardia (VT) of ectopic ventricular beats triggering heart failure and symptoms. We describe the treatment of a 16-years-old woman with late ToF repair and drug refractory Implantable cardioverter defibrillator (ICD) shocks. The patient underwent successful ablation of VT using X-ray and anatomic landmarks without the use of electroanatomical mapping. We were able to reduce drugs after one month of ablation and improve quality of life and symptoms. In this paper we describe the indications and perform a brief review of the key points for successful radiofrequency catheter ablation of VT in ToF patients.

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Ventricular Arrhythmia in Tetralogy of Fallot Repair Using Catheter Ablation

Valdigem¹,

Moreira²,

Andalaft³

et al. 2018

Braz J Cardiovasc Surg

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“…This study's methodology has been previously described when assessing the 30-day results 17 . In the first state of the treatment, ninety consecutive symptomatic patients were randomized (double-blind) to receive either 3.0 g/day of MgP, the equivalent of 260 mg of the Mg element, or placebo, for 30 days.…”

Section: Methodsmentioning

confidence: 99%

“…The follow-up visits were monthly conducted to assess symptoms by using a specific questionnaire. As previously described 17 , the questionnaire was elaborated with the following questions: 1- failures or "leaps", like a 'somersault' in the chest; 2- cough with palpitations; 3- dizziness; 4- dyspnea; 5- sweating and/or chest pain. According to the frequency of symptoms, points were attributed, which resulted in a score, and a two-point drop was considered a criterion of improvement.…”

Section: Methodsmentioning

confidence: 99%

“…In selected patients, based on a simple treatment strategy, antiarrhythmics drugs, which can be harmful or poorly tolerated under certain circumstances, can be avoided. Recently, we have shown that Mg pidolate (MgP), after a 30-day continuous supplementation, can decrease ectopic beats and improve related symptoms 17 . Based on those initial findings, we assessed the outcome of this cohort of patients in the late follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Late Outcome of a Randomized Study on Oral Magnesium for Premature Complexes

Falco

Darrieux

Grupi

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundVentricular and supraventricular premature complexes (PC) are frequent and usually symptomatic. According to a previous study, magnesium pidolate (MgP) administration to symptomatic patients can improve the PC density and symptoms.ObjectiveTo assess the late follow-up of that clinical intervention in patients treated with MgP or placebo.MethodsIn the first phase of the study, 90 symptomatic and consecutive patients with PC were randomized (double-blind) to receive either MgP or placebo for 30 days. Monthly follow-up visits were conducted for 15 months to assess symptoms and control electrolytes. 24-hour Holter was performed twice, regardless of symptoms, or whenever symptoms were present. In the second phase of the study, relapsing patients, who had received MgP or placebo (crossing-over) in the first phase, were treated with MgP according to the same protocol.ResultsOf the 45 patients initially treated with MgP, 17 (37.8%) relapsed during the 15-month follow-up, and the relapse time varied. Relapsing patients treated again had a statistically significant reduction in the PC density of 138.25/hour (p < 0.001). The crossing-over patients reduced it by 247/hour (p < 0.001). Patients who did not relapse, had a low PC frequency (3 PC/hour). Retreated patients had a 76.5% improvement in symptom, and crossing-over patients, 71.4%.ConclusionSome patients on MgP had relapse of symptoms and PC, indicating that MgP is neither a definitive nor a curative treatment for late follow-up. However, improvement in the PC frequency and symptoms was observed in the second phase of treatment, similar to the response in the first phase of treatment.

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“…The best original manuscript of 2011 included two original articles on basic research on the effects of coffee residues in the metabolism of rats 2 and the influence of chronic stress on myocardial function in rats 3 . Clinical studies about the influence of carvedilol on oxidative stress in chronic Chagas' heart disease 4 and density reduction of ventricular premature beats and symptoms after administration of magnesium 5 were also awarded. Finally, the assessment of myocardial delayed enhancement technique for magnetic resonance imaging in identifying higher risk for ventricular tachycardia in Chagas' heart disease 6 completed a wide variety of highquality publications from Brazilian scientific research studies published in our journal.…”

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confidence: 99%

Mensagem Do Editor

Moreira¹

2013

Arq. Bras. Cardiol.

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Redução da densidade de extrassístoles e dos sintomas relacionados após administração de magnésio por via oral

Abstract: Background: Premature ventricular and supraventricular complexes (PVC and PsVC) are frequent and often symptomatic. The magnesium (Mg) ion plays a role in the physiology of cell membranes and cardiac rhythm.

Cited by 11 publications

References 23 publications

Successful Treatment of Ventricular Arrhythmia in Tetralogy of Fallot Repair Using Catheter Ablation

Successful Treatment of Ventricular Arrhythmia in Tetralogy of Fallot Repair Using Catheter Ablation

Late Outcome of a Randomized Study on Oral Magnesium for Premature Complexes

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