2011
DOI: 10.1590/s0066-782x2011005000072
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Abstract: A large body of evidence has suggested the existence of a reflex network that becomes hyperactive secondary to musculoskeletal alterations that occur in heart failure (HF) syndrome. Together with sympathoinhibitory cardiovascular reflexes, suppressed in the presence of the syndrome, heart failure can contribute to physical exercise intolerance. The hyperactivation of signals originated from receptors located in skeletal muscles (mechanoreceptors -metaboreceptors) is a recently proposed hypothesis to explain th… Show more

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Cited by 17 publications
(10 citation statements)
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“…During exercise recovery HR decreases in a mono-exponential way 23 , and this behavior is related to the reactivation of parasympathetic activity, the level of physical condition and exercise intensity 24 , its recovery in the 1st minute after exercise being regarded as an important predictor of mortality 25 . HR recovery was observed in both protocols from the 7th minute of recovery.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…During exercise recovery HR decreases in a mono-exponential way 23 , and this behavior is related to the reactivation of parasympathetic activity, the level of physical condition and exercise intensity 24 , its recovery in the 1st minute after exercise being regarded as an important predictor of mortality 25 . HR recovery was observed in both protocols from the 7th minute of recovery.…”
Section: Discussionmentioning
confidence: 99%
“…Metabolic accumulation, as a result of elevated cellular metabolism, promotes the activation of the metaboreceptors. As a consequence, the stimulation of the non-myelinated afferent fibers leads to sympathetic activity, resulting in an increase in HR, cardiac output, BP and vasoconstriction in non-active muscles 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Also, levosimendan infusion acting via sensitization of cardiac troponin C to calcium and by opening ATP-sensitive potassium channels did not increase pulmonary VE [27]. Regarding R-BNP or levosimendan, effects on other inputs from the cerebral motor cortex and from peripheral afferents (baroreceptors and mechano-metaboeceptors) involved in hyperventilation control during exercise, there are not available published data [28]. However, it should be acknowledged that the precise mechanisms linking R-BNP and increased ventilation remain unclear.…”
Section: Discussionmentioning
confidence: 89%
“…We reported significant changes between groups regarding HR recovery from maximal effort (slower recovery in the group with moderate/high risk groups), however, there was no difference between groups in recovery of HR from moderate aerobic exercise. Previous studies exhibited that post-exercise HR recovery is related to vagal reactivation, exercise characteristics and general physical fitness level 33 , which is considered a reliable predictor of mortality 34 . In this study, both groups exhibited similar recovery of HR, which was anticipated because they were healthy and physically active individuals.…”
Section: Discussionmentioning
confidence: 99%