Exercício e restrição alimentar aumentam o RNAm de proteínas do trânsito de Ca2+ miocárdico em ratos

Abstract

Background: Chronic exercise and food restriction (FR) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (TH) status.

Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats

“…In the present study, there was an increase in the RYR2 receptor expression in both trained groups (LZR + TR and OZR + TR) compared with their controls (LZR and OZR). Our findings were different from those found in a study with rats submitted to AET and food restriction, where no significant change in RYR2 receptor expression was found [ 35 , 36 ]. This could be because the swimming training was most effective to promote this adaptation in obesity phenotype.…”

Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats

“…Some studies have evaluated the effect of aerobic training over the alterations on SERCA2a and NCX1 (Rolim et al, 2007;Sugizaki et al, 2011;Bupha-Intr et al, 2009;Jiao et al, 2012). Corroborating with our result, a study using SHR has demonstrated that the exercise training was able to increase the protein levels of SERCA2a; in addition to any alteration on the NCX1 protein levels (Garciarena et al, 2009).…”

Moderate exercise training does not prevent the reduction in myocardial L-type Ca2+ channels protein expression at obese rats

“…LTCCs have been also implicated as a possible site of adaptation by ET, but in the literature data are conflicting (Mokelke et al 1997;Wang et al 2008). There are studies that show ET eliciting adaptations in myocardial L-type Ca 2+ channel function and expression (Wang et al 2008;Sugizaki et al 2011), but others do not confirm these responses (Mokelke et al 1997). In this study, the obesity promoted downregulation LTTC without prejudice to activity.…”

“…In obese rats, after obesity chronic exposure, authors proposed prevention in cardiac dysfunction by MET associated with attenuating the reduction in expression of regulatory proteins of Ca 2+ handling, but the specific effects of exercise training on LTCCs have not been investigated (Paulino et al 2010). Although some studies have showed that exercise training promotes positive adaptations and increase gene expression of these channels (Wang et al 2008;Sugizaki et al 2011), other researchers have proposed that there were no alterations in Ca 2+ influx current by endurance training (Mokelke et al 1997).…”