Preditores de função ventricular esquerda global na síndrome metabólica

Ivanović, Branislava; Tadić, Marijana; Simić, Dragan

doi:10.1590/s0066-782x2011005000039

Cited by 5 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metabolic syndrome (MetS) presents a significant group of risk factors for cardiovascular morbidity and mortality [1][2][3][4] and constitutes a major public health problem with increasing incidence and prevalence, in recent decades [5][6] . MetS has been shown to be associated with structural and functional heart disturbances [7][8] , including left ventricular (LV) diastolic dysfunction [9][10] , coronary artery disease [11][12] and arterial and ventricular stiffness [13][14] .…”

Section: Introductionmentioning

confidence: 99%

Impaired Left Atrial Reservoir Function in Metabolic Syndrome Predicts Symptoms in HFpEF Patients

Berisha¹,

Bajraktari²,

Ibrahimi³

et al. 2015

ICFJ

View full text Add to dashboard Cite

Background and Aim. The Metabolic Syndrome (MetS) has been shown to be independently associated with increased risk for incident heart failure (HF) and coronary artery disease. The aim of this study was to investigate the additional effect of MetS on LA dysfunction in a group of patients with HF and preserved ejection fraction (HFpEF) and its relationship with symptoms.Methods. This study included 194 consecutive patients (age 62 ± 9 years) with stable HFpEF. LV dimensions, ejection fraction (EF), mitral annulus peak systolic excursion (MAPSE), myocardial velocities (s’, e’ and a’), LA dimensions and volumes were measured. Total LA emptying fraction (LA EF) was measured by Simpson rule volumes. Based on the NCEP-ATP III criteria, patients were divided into two groups; MetS (n=95) and non-MetS (n=108) and were compared with 34 age and gender matched controls.Results. Age and gender were not different between patients and control neither between MetS and non-Met. LV dimensions, EF and longitudinal function indices were also not different. The MetS patients had higher LV mass index (p=0.038), lower septal and lateral e’ (p=0.003 and p=0.001, respectively) velocities, larger LA minimal volume (p=0.007) and lower LA EF (p<0.001) compared with the non-MetS patients. Age, LA EF and MetS independently predicted the NYHA class.Conclusions. Despite no difference in LV systolic function, patients with HFpEF and MetS have worse LA emptying fraction, compared with HFpEF and non-MetS patients. In addition, LA reservoir function impairment and MetS independently predict patients limiting symptoms, thus add to a better understanding of HFpEF.

show abstract