Alterações metabólicas, terapia antirretroviral e doença cardiovascular em idosos portadores de HIV

Krämer, Andrea; Lazzarotto, Alexandre Ramos; Sprinz, Eduardo; Manfroi, Waldomiro Carlos

doi:10.1590/s0066-782x2009001100019

Cited by 35 publications

(29 citation statements)

References 71 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Idosos em geral são mais propensos a comorbidades que necessitam de tratamento contínuo com vários medicamentos e, por causa da aids, o uso de antirretrovirais poderá acarretar interações medicamentosas em seu organismo, como também dificuldade em utilizar todos esses medicamentos nos horários corretos. 8,24 Em relação às doenças oportunistas ou intercorrên-cias apresentadas, destacaram-se a candidíase, seguida pela diarreia, anemia, pneumonia e tuberculose. Essas doenças e intercorrências são facilmente confundidas com sintomas associados a várias afecções comuns nessa faixa etária.…”

Section: Discussionunclassified

Perfil de pessoas idosas vivendo com HIV/aids em Pelotas, sul do Brasil, 1998 a 2013

Affeldt¹,

Silveira²,

Barcelos³

2015

Epidemiol. Serv. Saúde

View full text Add to dashboard Cite

Section: Discussionunclassified

Perfil de pessoas idosas vivendo com HIV/aids em Pelotas, sul do Brasil, 1998 a 2013

Affeldt¹,

Silveira²,

Barcelos³

2015

Epidemiol. Serv. Saúde

View full text Add to dashboard Cite

“…Another metabolic alteration has been reported in HIV lipodystrophy syndrome (SLD), known as fat redistribution syndrome, which causes an accumulation of fat in the dorso-cervical (buffalo hump) and abdominal region. Fat redistribution with abdominal lipohypertrophy predisposes the patient to cardiovascular disease risk due to visceral fat, directly associated with a higher incidence of changes in serum lipids and insulin resistance, with a rise in risks for the development of Type 2 diabetes [16]. This study is well established as shown in Table 2, classification of cardiovascular risk in these patients have a higher prevalence of medium and high risk.…”

Section: Discussionmentioning

confidence: 75%

Metabolic Syndrome in People with HIV/AIDS

Werberich¹,

Ceren²,

Romancini³

et al. 2013

WJA

View full text Add to dashboard Cite

Background: Highly Active Antiretroviral Therapy (HAART) has changed the clinical picture of HIV infection by reducing morbidity and mortality rates in the population. However, alterations in lipid metabolism leading to hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat, which are risk factors for cardiovascular diseases, have emerged. Metabolic Syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors commonly associated with central adiposity and insulin resistance. Aim: Current paper evaluates the prevalence of MS in patients with HIV/AIDS using HAART from a reference Center in southern Brazil. Methods: Samples comprised patients who had the infection for at least five years and were undergoing antiretroviral therapy. Metabolic syndrome was identified according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII). A physical examination was performed by evaluating percentage of body fat by bio-impedance and measuring blood pressure, determination of Body Mass Index and Waist-Hip Ratio, glycaemia, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: 184 patients were evaluated. MS prevalence was 30% (55 patients), with 30 (16.3%) males and 25 (13.7%) females. Conclusions: Brazil was among the first country profoundly impacted by the HIV/AIDS epidemic but today, Brazil has less than 1% adult HIV prevalence, implemented treatment and prevention programs early in the epidemic. Whereas there is currently a significant increase in the survival of HIV patients by HAART, the patients reveal a higher prevalence of Metabolic Syndrome in this specific population requiring political strategy of care to this population.

show abstract

“…This fat redistribution with abdominal lipohypertrophy predisposes to risk of cardiovascular diseases, due to the visceral fat direct association with higher incidence of serum lipid alterations as well as insulin resistance, increasing hence the risk of development of type 2 diabetes 18 . Kramer 19 reported dyslipidemia in the HIV patient who makes use of HAART characterized by increased VLDL (the greatest triglyceride transporter) and LDL-cholesterol levels and reduction of the HDL-cholesterol level. The authors also suggest that the facts which would lead the HIV patient to present dyslipidemias are not totally elucidated yet.…”

Section: Discussionmentioning

confidence: 99%

Níveis de atividade física e alterações metabólicas em pessoas vivendo com HIV/AIDS

Romancini

Guariglia

Nardo

et al. 2012

Rev Bras Med Esporte

View full text Add to dashboard Cite

The introduction of Highly Active Antiretroviral Therapy (HAART) has deeply changed the course of HIV infection with increase in survival and improvement in quality of life as well as partial restoration of the immune system. After about ten years from the HAART use, the effects of combination treatment / virus started to come out. Among these, we can mention changes in lipid metabolism with hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat as risk factors for cardiovascular disease. Observational studies with people living with HIV / AIDS evidence that when an individual finds out that he/she is an HIV/AIDS patient, he/she end ups feeling fear or shame, reducing hence social circle, work and leisure activities, and becomes isolated at home or in small groups which have common identity of HIV / AIDS patients. The purpose of this work was to evaluate the relationship between the level of habitual physical activity and recreation of people living with HIV / AIDS and its relation with metabolic changes. The patients were classified into active and sedentary, using the Habitual Physical Activity questionnaire proposed by Baecke and validated for HIV / AIDS patients. Classification was conducted according to the recommendations of the American College of Sports Medicine. Metabolism was assessed through plasma levels of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides, using commercial kits. The sample consisted of 65 HIV patients who used HAART for at least five years. 64.6% were classified as sedentary and 35.4% as active. The study shows a direct relationship between physical activity level and higher levels of HDL -cholesterol in HIV / AIDS. HDL -Cholesterol is a lipoprotein of cardiovascular protection and, although other assessed parameters have not shown difference, these results highlight the need for additional studies on risk factors and physical activity for HIV / AIDS enabling proposals for specific interventions for these patients.

show abstract

Alterações metabólicas, terapia antirretroviral e doença cardiovascular em idosos portadores de HIV

Cited by 35 publications

References 71 publications

Perfil de pessoas idosas vivendo com HIV/aids em Pelotas, sul do Brasil, 1998 a 2013

Perfil de pessoas idosas vivendo com HIV/aids em Pelotas, sul do Brasil, 1998 a 2013

Metabolic Syndrome in People with HIV/AIDS

Níveis de atividade física e alterações metabólicas em pessoas vivendo com HIV/AIDS

Contact Info

Product

Resources

About