2009
DOI: 10.1590/s0066-782x2009000500013
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Abstract: Oxidative stress is increased in CKD patients free of CVD and is associated with endothelial dysfunction in patients and controls. The results suggest that oxidative stress and endothelial dysfunction may be involved in the increased susceptibility of CKD patients to CVD and cardiovascular complications.

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Cited by 24 publications
(12 citation statements)
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References 13 publications
(10 reference statements)
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“…So far our results indicate that the uremic toxins alter the biological activities of endothelial cells in vitro , and are in accordance with previously published data [26], [27], [28], [29], [30]. Nevertheless, previous studies have been focused on the response of endothelial cell ( in vitro ) after long term stimulation with inflammatory stimuli or of the endothelium ( in vivo ) under conditions of systemic inflammation.…”
Section: Resultssupporting
confidence: 92%
“…So far our results indicate that the uremic toxins alter the biological activities of endothelial cells in vitro , and are in accordance with previously published data [26], [27], [28], [29], [30]. Nevertheless, previous studies have been focused on the response of endothelial cell ( in vitro ) after long term stimulation with inflammatory stimuli or of the endothelium ( in vivo ) under conditions of systemic inflammation.…”
Section: Resultssupporting
confidence: 92%
“…However, many epidemiological studies have suggested that increased γ-GTP levels may be a precocious and sensitive marker of oxidative stress, identifying persons with low, but persistent, augmentation of nonalcoholic fatty liver disease [24]. Serum TBARS levels are elevated in chronic kidney disease patients [25,26]. TBARS interferes with nitric oxide generation through competitive inhibition of nitric oxide (NO)-synthase enzyme, and therefore may lead to impairent in endothelium NO pathway in kidney [25-27].…”
Section: Discussionmentioning
confidence: 99%
“…Serum TBARS levels are elevated in chronic kidney disease patients [25,26]. TBARS interferes with nitric oxide generation through competitive inhibition of nitric oxide (NO)-synthase enzyme, and therefore may lead to impairent in endothelium NO pathway in kidney [25-27]. Endothelial dysfunction is a common event described both in chronic and acute renal failure [27].…”
Section: Discussionmentioning
confidence: 99%
“…O endotélio é estimulado a produzir e liberar NO pelo aumento do fluxo sanguíneo e consequente incremento do shear stress, resultando em vasodilatação. Este fenômeno é denominado vasodilatação mediada pelo fluxo (VMF) e, como depende da integridade do endotélio, pode também ser denominada de vasodilatação dependente do endotélio 51,52 .…”
Section: Doença Renal Crônica E Alterações Vascularesunclassified
“…Costa-Hong et al 52 observaram que pacientes com DRC apresentam comprometimento da reatividade vascular e sugerem que este fenômeno é causado pela uremia, e não por outras condições associadas. Segundo os autores, o comprometimento da reatividade vascular, embora envolva a vasodilatação dependente e independente de endotélio, parece ser devido, primariamente, à disfunção endotelial.…”
Section: Doença Renal Crônica E Alterações Vascularesunclassified