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Cited by 10 publications
(6 citation statements)
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“…These findings support the hypothesis that in fetal life, ventricular septal defect and low left ventricular afterload relieve the pressure overload imposed by the obstruction of the right ventricular outflow tract, decreasing the stimulus for right ventricular remodeling. 20 After birth the physiological increase in afterload of the left ventricle, which is reflected in the right ventricle through the ventricular septal defect, adds to that imposed by the obstruction of the right ventricular outflow tract, generating great stimulus to right ventricular remodeling. Thus, we can consider that the right ventricular remodeling possibly occurs mainly in the post-natal period.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…These findings support the hypothesis that in fetal life, ventricular septal defect and low left ventricular afterload relieve the pressure overload imposed by the obstruction of the right ventricular outflow tract, decreasing the stimulus for right ventricular remodeling. 20 After birth the physiological increase in afterload of the left ventricle, which is reflected in the right ventricle through the ventricular septal defect, adds to that imposed by the obstruction of the right ventricular outflow tract, generating great stimulus to right ventricular remodeling. Thus, we can consider that the right ventricular remodeling possibly occurs mainly in the post-natal period.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, we can consider that the right ventricular remodeling possibly occurs mainly in the post-natal period. 20 Right ventricular hypertrophy is a secondary response to increased afterload. There are a few additional changes that occur with some frequency in this disease: obstruction at the level of branches of the pulmonary artery, coronary anomalies, right aortic arch, and additional defects in the interventricular septum.…”
Section: Discussionmentioning
confidence: 99%
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“…Quantitative assessment was performed from the captured images on the computer screen scored in a blinded manner and mean values were calculated. Diameter of cardiomyocytes was measured along a line intercepting the cell nucleus in 100 cells per animal (Farah et al 2009). Length of the cardiomyocyte nucleus was measured along a line that intercepted the respective nucleus in 100 cells per animal (Noszczyk-Nowak et al 2009).…”
Section: Histological Processing Of Heart Thoracic Aorta and Kidneysmentioning
confidence: 99%
“…Isto está de acordo com a idéia de que embora o estresse biomecânico ocorra num ventrículo, neste caso o direito, esse desencadeia vias bioquímicas e neuro-humorais que atuariam também no ventrículo contralateral(Frey e Olson, 2003). Em estudo anterior(Farah, 2008; in press) realizado com amostras coletadas de peças anatômicas de tetralogia de Fallot, havíamos encontrado valores de fração de área de colágeno em média pouco acima ou no limite superior do normal para as amostras do ventrículo direito, e valores dentro dos limites normaispara o ventrículo esquerdo. Considerando que a técnica utilizada para medir o colágeno intersticial nos dois estudos foi a mesma, assim como os equipamentos e o observador, considera-se a possibilidade de que algum fator envolvido na conservação destas peças por vários anos, talvez o formol, possa de algum modo ter interferido na capacidade do colágeno intersticial ser corado pela técnica de picrosirius.…”
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