“…However, the pathogenesis of hyponatremia in edematous patients is much-debated and has not been completely elucidated yet. Particularly, some authors argue in favor of a causative role of particular biohumoral patterns (poorly controlled RAAS overactivation [8,9,10], excess of BNP release [11,12], relative adrenal insufficiency [13,14]), and controversial therapeutic approaches (intensive intravenous diuretic therapy [4,6], and thiazides [15,16]), regarding both the pathogenesis and persistence over time of this electrolyte trouble.…”