2007
DOI: 10.1590/s0066-782x2007001600007
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Abstract: The use of hypertonic saline solution in patients with decompensated heart failure can be a safe therapeutic method and potentially related to clinical improvement and renal failure prevention.

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Cited by 17 publications
(8 citation statements)
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“…Indeed, both diuretics and vasodilators have the potential for inducing hypotension and relative arterial underfilling, thus eliciting further AVP release. Particularly, hyponatremia is likely to be mostly favored or provoked by erroneous and/or overzealous diuretic therapy [5,6]. Therefore, further impairment in effective arterial circulating volume has frequently been blamed on overly drastic or inappropriate diuretic therapy, resulting in the worsening of renal perfusion and fall in glomerular filtration rate (GFR) [7].…”
Section: Hyponatremia and Chronic Heart Failurementioning
confidence: 99%
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“…Indeed, both diuretics and vasodilators have the potential for inducing hypotension and relative arterial underfilling, thus eliciting further AVP release. Particularly, hyponatremia is likely to be mostly favored or provoked by erroneous and/or overzealous diuretic therapy [5,6]. Therefore, further impairment in effective arterial circulating volume has frequently been blamed on overly drastic or inappropriate diuretic therapy, resulting in the worsening of renal perfusion and fall in glomerular filtration rate (GFR) [7].…”
Section: Hyponatremia and Chronic Heart Failurementioning
confidence: 99%
“…However, the pathogenesis of hyponatremia in edematous patients is much-debated and has not been completely elucidated yet. Particularly, some authors argue in favor of a causative role of particular biohumoral patterns (poorly controlled RAAS overactivation [8,9,10], excess of BNP release [11,12], relative adrenal insufficiency [13,14]), and controversial therapeutic approaches (intensive intravenous diuretic therapy [4,6], and thiazides [15,16]), regarding both the pathogenesis and persistence over time of this electrolyte trouble.…”
Section: Hyponatremia and Chronic Heart Failurementioning
confidence: 99%
“…Mechanisms to explain the reduction in serum sodium could include restriction of sodium intake, loss of sodium due to the use of diuretics, and hemodilution 10 . However, the consequent hyponatremia could have potential deleterious effects, as it has been identified in several studies as a risk factor for increased morbidity and mortality in patients with heart failure.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, these data were generally from patients with cardiogenic shock resulting from right ventricular infarction 2. Another report also evaluated the use of hypertonic saline as an adjunct therapy in uncompensated heart failure patients and indicated that hypertonic saline had positive effects on renal function 3. In experimental models, hypertonic saline improved myocardial contractility,4 but its immediate impact on the hemodynamic profile during acute UHF has not been studied or reported to date.…”
Section: Discussionmentioning
confidence: 99%