Radioterapia mediastínica e lesão ostial de tronco de coronária esquerda

Victor, Edgar Guimarães; Parente, Giordano Bruno de Oliveira

doi:10.1590/s0066-782x2004000300011

Arq. Bras. Cardiol.

2004

DOI: 10.1590/s0066-782x2004000300011

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Radioterapia mediastínica e lesão ostial de tronco de coronária esquerda

Edgar Guimarães Victor¹,

Giordano Bruno de Oliveira Parente²

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Cited by 2 publications

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“…Mediastinal irradiation can lead to endothelial injury, fibroblast proliferation, collagen deposition, changes to the intima of the vessels, and acceleration of coronary disease [ 4 ] . When irradiation occurs in the anterior mediastinum, it is more damaging to the trunk of the left coronary artery [ 5 ] , the anterior descending, and the right coronary artery ostium, while the posterior irradiation affects mostly the circumflex artery [ 6 ] .…”

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confidence: 99%

Letters to the Editor

2014

Revista Brasileira De Cirurgia Cardiovascular

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mentioning

confidence: 99%

Letters to the Editor

2014

Revista Brasileira De Cirurgia Cardiovascular

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Isolated Left Main Coronary Artery Stenosis after Thoracic Radiation Therapy: To Operate or Not to Operate

Alsara

Alsarah

Kalavakunta

et al. 2013

Case Reports in Medicine

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Radiation therapy of neoplasms involving the chest or mediastinum results in a wide spectrum of cardiac complications including coronary artery disease, which can present in patients with few or no traditional cardiac risk factors. We report a case of radiation induced coronary artery disease in a 60-year-old female with a history of stage IIIA nonsmall cell lung carcinoma which was diagnosed eight years earlier and treated with chemotherapy and radiotherapy. She presented to the hospital with atypical chest pain that had occurred intermittently over the preceding week. Her initial electrocardiogram and cardiac enzymes were within normal limits. However, following an indeterminate exercise nuclear stress test, she developed chest pain and elevated cardiac enzymes. Coronary angiography demonstrated 90% stenosis of the left main coronary artery ostium, without any evidence of atherosclerotic disease or stenosis in other coronary arteries. She underwent surgical revascularization, which revealed dense adhesions surrounding the heart. During surgery, she developed severe bleeding and died. Coronary artery disease can present within years of radiation exposure, and ostial lesions are typical. Treatment is often challenging because of the effects of radiation on other tissues and the risks of revascularization procedures. Therefore, a multidisciplinary team approach should be considered.

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Radioterapia mediastínica e lesão ostial de tronco de coronária esquerda

Cited by 2 publications

References 7 publications

Letters to the Editor

Letters to the Editor

Isolated Left Main Coronary Artery Stenosis after Thoracic Radiation Therapy: To Operate or Not to Operate

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