Estudio fitoquímico de hojas de Uncaria guianensis y evaluación de actividad antibacteriana

Abstract

Del extracto de éter de petróleo de hojas de Uncaria guianensis (Rubiaceae), se aisló un compuesto tipo clorina denominado éster etílico de feoforbida a y una mezcla de esteroles conocidos como β-sitosterol y estigmasterol. Sus estructuras fueron elucidadas por análisis detallado de RMN, incluyendo técnicas bidimensionales, y por comparación con datos reportados en la literatura. Posteriormente, se evaluó la actividad antibacteriana al éster etílico de feoforbida a contra dos cepas Gram(+): S. aureus ATCC 6538 y E. faecalis ATCC 29212 y contra tres cepas Gram (-): E. coli ATCC 25922, S. typhimurium ATCC 14028s y S. typhimurium MS7953. Se encontró actividad significativa contra S. aureus, E. faecalis, E. coli y S. tiphymurium MS7953.

A scaffolded approach to unearth potential antibacterial components from epicarp of Malaysian Nephelium lappaceum L.

“…Similarly, the AC(S) extract fractions contained only 10 from 44 compounds with reported antibacterial activities (Table S4 ). Of these, except for L24 55 and L35 58 , all were reported recently. These included L2 44 , L5 62 , L10 48 , L13 52 , L19 54 , L36 58 , L38 59 and L42 61 .…”

“…Interestingly, most of them have been newly reported (within the last five years) including L2 42 , L3 43 , L6 44 , L10 46 , L12 47 , L16 48 , L20 49 , L22 51 , L26 52 , L28 53 , L31 54 , L46 58 , L48 59 , L51 60 , L53 61 and L54 59 . Others are known for some time, namely, L7 45 , L21 50 , L35 55 , L37 56 and L45 57 . Similarly, the AC(S) extract fractions contained only 10 from 44 compounds with reported antibacterial activities (Table S4 ).…”

Chromatographic Analyses, Virtual Screening and Pharmacokinetics of Yellow Malaysian Rambutan (Nephelium lappaceum L.) Fruit Epicarp Extracts Reveal Potential Antibacterial Compounds

“…Similarly, the AC extract fractions contained only 10 from 44 compounds with reported antibacterial activities(Table S4). Of these, except for L2451 and L3553 , all were reported recently. These included L2 40 , L5 58 , L10 44 , L13 48 , L19 50 , L3654 , L38 55 and L4257 .…”

“…Despite similar reports to our ndings by Mohamed et al L3 39 , L6 40 , L10 42 , L12 , L16 44 , L20 45 , L22 47 , L26 48 , L28 49 , L31 50 , L46 54 , L48 55 , L51 56 , L53 57 and L54 55 . Others are known for some time, namely, L7 41 , L21 46, L3551 , L37 52 and L4553. Similarly, the AC extract fractions contained only 10 from 44 compounds with reported antibacterial activities(Table S4).…”