Immunoglobulin E-rheumatoid factor in juvenile rheumatoid arthritis

Ferreira, Rondinele Alberto dos Reis; Ferriani, Virgínia Paes Leme; Sopelete, Mônica Camargo; Silva, Deise Aparecida Oliveira; Mineo, José Roberto; Kiss, Maria Augusta P. D.; Silva, Carlos Henrique Martins

doi:10.1590/s0041-87812002000500004

Cited by 8 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Again, it was noted that RF was more frequently detected using ELISA methods (33%) than by the traditional latex agglutination testing (6%). A previous study by this group had shown that IgE RF was not associated with severe disease in JIA [6].…”

Section: Rheumatoid Factorsmentioning

confidence: 75%

“…RFs are found in all Ig isotypes (eg, IgA, IgG, IgD, and IgE), but classically, 19S IgM RFs have mainly been used to assess rheumatic disease. Recently, IgA RF has been linked with severe disease in RA [4], but little significance has been placed on IgG RF and IgE RF in RA [5] and JIA [6]. Routine assays, including latex agglutination and nephelometry, only measure 19S IgM RFs, whereas enzyme-linked immunosorbent assays (ELISAs) have been designed to measure the various RF isotypes.…”

Section: Rheumatoid Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Syed

Gilliam²,

Moore

2008

Curr Rheumatol Rep

View full text Add to dashboard Cite

Juvenile idiopathic arthritis (JIA) is a heterogenous childhood disease without reliable biomarkers for monitoring disease progression. Immunoglobulin (Ig) M rheumatoid factor (RF) is used to define a subset of JIA patients, but its significance in JIA is dependent on the method of measurement. In addition to IgM RF, IgA RF has been implicated in determining disease severity in JIA, including functional disability and joint damage. Anticyclic citrullinated peptide (anti-CCP) antibodies have been a valuable diagnostic tool in rheumatoid arthritis, with varied results in their significance in JIA patients. Recent studies have demonstrated the possible usefulness of isotypes of anti-CCP antibodies in monitoring JIA patients to determine disease outcome. Overall, RF isotypes and anti-CCP isotypic antibodies have demonstrated increasing importance in the evaluation of JIA patients to determine which patients may have more aggressive or severe disease and to aid in possible treatment plans to prevent joint damage and disability.

show abstract

Section: Rheumatoid Factorsmentioning

confidence: 75%

Section: Rheumatoid Factorsmentioning

confidence: 99%

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Syed

Gilliam²,

Moore

2008

Curr Rheumatol Rep

View full text Add to dashboard Cite

show abstract

“…These include Kawasaki syndrome [75], vasculitides such as polyarteritis nodosa or Churg-Strauss syndrome[76], Guillian-Barre syndrome [77,78], inflammatory neuropathies [79], burns [80,81], Sjogren's syndrome [82], certain patients with rheumatoid arthritis who may also develop IgE rheumatoid factors [83], graft-versus-host disease and bone marrow transplantation [84] and scleroderma-like syndromes [85]. The prognostic or diagnostic role for IgE in these disorders is unknown…”

Section: Immune Dysregulation Associated With High Ige Levelsmentioning

confidence: 99%

Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective

et al. 2010

View full text Add to dashboard Cite

BackgroundAltered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.MethodsArticles published in Medline/PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination, deficiency and/or specific disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). The selected papers included reviews, case reports, retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis.ResultsBoth very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells, cytokines and T regulatory (or Treg) cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.ConclusionEvaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments.

show abstract

“…It is one of the major causes of joint destruction that results in functional disability and thus affects quality of life [1,2]. The aetiology of autoimmune RA is multifactorial and includes many parameters: genetic, immunological, environmental, hormonal, stress-related and environmental [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…However, RF is not unique to RA. It has also been found to occur in normal elderly individuals, healthy immunized individuals, and patients with other autoimmune diseases or chronic infections [2]. There are a number of other autoantibodies used as serological markers for RA such as antibodies against citrullinated proteins, filaggrin, calpastatin, and unknown antigen Sa [10,11].…”

Section: Introductionmentioning

confidence: 99%

Depression and Smoking Augment the Production of Circulating Autoantibodies against Glycated HSA in Rheumatoid Arthritis Patients

Alouffi

Sherwani

Al-Mogbel

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advanced glycation end products (AGEs) are also detected in RA patients. This study correlates RA in patients with various levels of depression and a history of smoking through the detection of antibodies against AGEs of proteins. Methods: Sixty RA subjects were selected and divided into 4 groups based on their levels of depression and smoking habits. The division was as follows: group I consisted of RA patients classified as depressed (RA-D); group II consisted of RA patients with a history of smoking (RA-S); group III consisted of RA patients suffering from depression who were also smokers (RA-DS); and group IV consisted of patients with RA alone (RA-A), i.e., not depressed and non-smokers. In vitro human serum albumin (HSA) was modified by glucose, and the modifications were studied by biochemical and biophysical techniques. Glycated (G)-HSA was used as an antigen, and autoantibodies against G-HSA (G-HSA-Abs) were screened in serum samples of different groups of RA subjects. Oxidative stress levels in all patients and healthy individuals were analyzed by protein-bound carbonyl content estimations. Results: Significant biochemical and biophysical changes were detected in G-HSA when compared to native (N)-HSA. All patients and control subjects were screened for circulating G-HSA-Abs and N-HSA-Abs. From the cohort of different samples, serum autoantibodies from RA-DS showed a high recognition of G-HSA-Abs titres compared to RA-D or RA-S. RA-A exhibited the least binding of circulating G-HSA-Abs of all the groups. The oxidative stress marker, the carbonyl content also exhibited highest levels in RA-DS, followed by RA-D and RA-S. Band shift assay showed the highest titres of immunoglobulin G in the serum samples of RA-DS. Conclusions: Smoking and concomitant depression in RA subjects may lead to enhanced oxidative stress levels responsible for the gradual formation and/or exposing of cryptic epitopes on HSA that induce the production of G-HSA-Abs. Hence, we postulate that by reducing depression and corresponding oxidative stress, it may be possible to control or limit the severity of the precipitation of RA disease activity and improve prognosis.

show abstract

Immunoglobulin E-rheumatoid factor in juvenile rheumatoid arthritis

Cited by 8 publications

References 17 publications

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective

Depression and Smoking Augment the Production of Circulating Autoantibodies against Glycated HSA in Rheumatoid Arthritis Patients

Contact Info

Product

Resources

About