2002
DOI: 10.1590/s0041-87812002000200001
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Abstract: PURPOSE:Two groups of girls with premature breast development were studied retrospectively. We tried to identify clinical, radiological, and hormonal parameters that could distinguish between a benign, nonprogressive premature thelarche and a true precocious puberty. METHODS:The clinical outcome of 88 girls with breast enlargement before 6.1 years of age was analyzed. Taking into account the progression of their sexual maturation, we allocated the children into 2 groups: "Isolated Premature Thelarche" (n = 63)… Show more

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Cited by 18 publications
(6 citation statements)
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“…In the studies carried out by Della Manna et al (31) and Ilicki et al (32), sex steroids were found to be comparable in cases with PT and PP. In our study, estradiol levels were higher in the PP cases.…”
Section: Discussionmentioning
confidence: 85%
“…In the studies carried out by Della Manna et al (31) and Ilicki et al (32), sex steroids were found to be comparable in cases with PT and PP. In our study, estradiol levels were higher in the PP cases.…”
Section: Discussionmentioning
confidence: 85%
“…Della Manna et al (13) also reported tall stature, accelerated growth rate and bone age, increased uterine and ovarian volumes, and high spontaneous LH levels in the precocious puberty group. They found the growth velocity below the 90th percentile in 78% of idiopathic premature thelarche patients, whereas in the precocious puberty group, 76% were girls with 90th percentile.…”
Section: Discussionmentioning
confidence: 95%
“…There are few studies about the natural history of premature thelarche, and their conclusions are controversial. A recent study, on a large number of patients with premature thelarche [Della Manna et al, 2002], suggests that clinical, radiological, and hormonal findings at initial presentation may clearly distinguish patients who will undergo true precocious puberty. Nevertheless, Pasquino et al [1995] have demonstrated that premature thelarche is not always a self‐limited condition and may sometimes accelerate the timing of puberty thus suggesting the importance of follow‐up studies in these patients.…”
Section: To the Editormentioning
confidence: 99%