Megabladder in experimental Chagas disease: pathological features of the bladder wall

Scremin, Luciano Henrique Gazoni; Corbett, Carlos Eduardo Pereira; Laurenti, Márcia Dallastra; Nunes, Elizabeth Visone; Gama-Rodrigues, Joaquim; Okumura, Masayuki

doi:10.1590/s0041-87811999000200003

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Figure 9.3 shows a comparison of the MRI of the normal bladder of a control mouse and the enlarged flaccid bladder of an infected mouse. Although there had been only rare descriptions of megaureter in humans (Koeberle, 1968), megabladder had been reported before in experimental T. cruzi infection in mice and dogs (Barr et al, 1991; Scremin et al, 1999). Hepatosplenomegaly has also been reported in patients with Chagas disease, and we have observed enlargement of both the spleen and the liver in mice infected with the Brazil strain of T. cruzi .…”

Section: 3 Mouse Modelsmentioning

confidence: 99%

Advances in Imaging of Animal Models of Chagas Disease

Jelicks¹,

Tanowitz²

2011

Advances in Parasitology

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Since serial studies of patients are limited, researchers interested in Chagas disease have relied on animal models of Trypanosoma cruzi infection to explore many aspects of this important human disease. These studies have been important for evaluation of the immunology, pathology, physiology and other aspects of pathogenesis. While larger animals have been employed, mice have remained the most favoured animal model, as they recapitulate many aspects of the human disease, are easy to manipulate genetically and are amenable to study by small animal imaging technologies. Further, developments in non-invasive imaging technologies have permitted the study of the same animal over an extended period of time by multiple imaging modalities, thus permitting the study of the transition from acute infection through the chronic stage and during therapeutic regimens.

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Section: 3 Mouse Modelsmentioning

confidence: 99%

Advances in Imaging of Animal Models of Chagas Disease

Jelicks¹,

Tanowitz²

2011

Advances in Parasitology

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“…These megasyndromes are coupled with gastrointestinal motility disturbances in patients with Chagas disease (Madrid et al 2004; Madrid and Defilippi 2006). Mega-organ syndromes and associated symptoms are also exhibited in animal models of Chagas disease (Postan et al 1986; 1987; Scremin et al 1999; De Rossell et al 2000; Boczko et al 2005). Recently, in separate studies, we demonstrated decreased intestinal motility in T. cruzi (Y strain) infected Swiss Webster mice (de Oliveira et al 2008) and intestinal dilation in T. cruzi (Brazil strain) infected C57Bl/6 mice (Ny et al 2008).…”

Section: Introductionmentioning

confidence: 99%

The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection

Souza

Sieberg

et al. 2010

Parasitol Res

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Infection with Trypanosoma cruzi causes mega-syndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to noninvasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruziinfected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased

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“…Mice exhibit many of the functional, pathologic, and immunologic alterations observed in human infection, including cardiomyopathy and mega-organ syndromes 5,11–14. Mori and others15 used x-ray methods to investigate GI tract abnormalities in T. cruzi –infected mice.…”

Section: Introductionmentioning

confidence: 99%

A Magnetic Resonance Imaging Study of Intestinal Dilation in Trypanosoma cruzi–infected Mice Deficient in Nitric Oxide Synthase

Ny¹,

Li²,

Mukherjee³

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract. We used magnetic resonance imaging (MRI) to monitor alterations in the GI tract of T. cruzi-infected mice, and to assess the role of nitric oxide (NO) in the development of intestinal dilation. Brazil strain-infected C57BL/6 wild-type (WT) mice exhibited dilatation of the intestines by 30 days post-infection. Average intestine lumen diameter increased by 72%. Levels of intestinal NO synthase (NOS) isoforms, NOS2 and NOS3, were elevated in infected WT mice. Inflammation and ganglionitis were observed in all infected mice. Intestinal dilation was observed in infected WT, NOS1, NOS2, and NOS3 null mice. This study demonstrates that MRI is a useful tool to monitor intestinal dilation in living mice and that these alterations may begin during acute infection. Furthermore, our data strongly suggests that NO may not be the sole contributor to intestinal dysfunction resulting from this infection.

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Megabladder in experimental Chagas disease: pathological features of the bladder wall

Cited by 5 publications

References 5 publications

Advances in Imaging of Animal Models of Chagas Disease

Advances in Imaging of Animal Models of Chagas Disease

The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection

A Magnetic Resonance Imaging Study of Intestinal Dilation in Trypanosoma cruzi–infected Mice Deficient in Nitric Oxide Synthase

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