Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency

Silva, Maria Teresa Nascimento; Costa, Vlaudia Maria Assis; Pereira, Teobaldo G. R.; Sales, Iana Rafaela Fernandes; Silva, Silvana Ferreira da; Maciel, Maria Amélia Vieira; Malagueño, Elizabeth; Souza, Valdênia Maria Oliveira de

doi:10.1590/s0037-86822012000600021

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Helminth infection may modulate immune responses by inducing an anti-helminthic T H 2 cytokine-dominated milieu, which may result in an allergic phenotype once the infection is removed. 88,89 Evidence in support of this comes for instance from a large placebo-controlled trial in a helminth-endemic region of Uganda, whereby treatment with albendazole during the third trimester of pregnancy was associated with an increased prevalence of AD in offspring up to 1 year. 48,90 In contrast, a randomized placebo-controlled trial of helminth eradication in a helminth-endemic area in Vietnam found no effect on the prevalence of AD in schoolchildren, when anti-helminthic treatment was administered to schoolchildren, highlighting that there may be a critical time window for immuno-modulation at the gut interface during the perinatal period.…”

Section: Gut Microbiome and Dietary Influencesmentioning

confidence: 99%

“…The role of the microbiome is expanded further when helminth parasites and their relationship to AD development are considered. Helminth infection may modulate immune responses by inducing an anti‐helminthic T H 2 cytokine–dominated milieu, which may result in an allergic phenotype once the infection is removed 88,89. Evidence in support of this comes for instance from a large placebo‐controlled trial in a helminth‐endemic region of Uganda, whereby treatment with albendazole during the third trimester of pregnancy was associated with an increased prevalence of AD in offspring up to 1 year 48,90.…”

Section: The Role Of the Microbiomementioning

confidence: 99%

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The exposome in atopic dermatitis

Stefanovic

Flohr

Irvine

2019

Allergy

128

103

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Atopic dermatitis (AD) (syn. atopic eczema) is a chronic inflammatory skin condition, affecting up to 20% of children and 5%-10% of adults. 1,2 Current understanding of AD pathogenesis points towards a sophisticated interplay between genetic and environmental factors. The pathogenesis of AD may start in many cases with a genetically predetermined skin barrier defect, which manifests itself as dry skin. This inherent skin barrier deficit leads to an overexpression of pro-inflammatory cytokines and subsequently the activation of innate lymphocyte subsets and antigen-presenting cells (T H 2 and T H 22). IL-4 and IL-13 in particular drive eosinophil and mast cell recruitment and IL-31 secretion, a key cytokine involved in itch sensation. 3 Transcutaneous sensitization to environmental allergens and bacterial infections, in particular Staphylococcus aureus, further contributes to the barrier disruption and eczematous skin inflammation. While a genetic barrier defect is present in many, this is not a prerequisite and many pathological pathways can lead to AD. There

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Section: Gut Microbiome and Dietary Influencesmentioning

confidence: 99%

Section: The Role Of the Microbiomementioning

confidence: 99%

The exposome in atopic dermatitis

Stefanovic

Flohr

Irvine

2019

Allergy

128

103

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“…Very importantly, growing evidence indicates that these helminthiases increase susceptibility to other life-threatening infections such as malaria, tuberculosis, and HIV/AIDS [5-7]. In turn, some human studies have shown that intestinal helminths can modulate the occurrence of allergies and asthma [8], alter the course of some autoimmune diseases such as multiple sclerosis [9] and inflammatory bowel disease [10], among others. The latter studies lend renewed support the “hygiene hypothesis” [11,12], more recently called the “Old Friends Hypothesis” [13].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-10 and soil-transmitted helminth infections in Honduran children

2015

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BackgroundSoil-transmitted helminths (STH) establish chronic infections in the human intestine. The host reacts to these infections with a dominant T-helper type 2 cell (Th2) response that while attempting to control the worm population, can also provide an anti-inflammatory environment favourable for parasite survival. Regulatory cytokine interleukin 10 (IL-10) has been proposed as a key molecule involved in the attenuation of chronic inflammation and the ensuing tolerance for these helminth parasites. The objective of this study was to determine whether STH-infected children from an endemic community had increased circulating IL-10 levels when compared to non-infected children.ResultsA total of 39 children (25 boys and 14 girls, 7–15 years of age) were enrolled in study. Utilizing the Kato-Katz method to detect intestinal helminthiases, 10 children were non-infected and 29 were harbouring STH infections by Ascaris lumbricoides, Trichuris trichiura and/or hookworms. Of the 29 infected children, 11 had single-species infections and 18 were polyparasitized with two or three STH species. Serum samples from all 39 children were tested for IL-10 serum concentrations, out of which 12 had undetectable levels while 27 had levels ranging from 0.4-105 pg/mL. Excluding extreme outlying values, 25 samples had IL-10 concentration values ranging from 0.4 -7.2 pg/mL. Differences in IL-10 levels among non-parasitized, monoparasitized, and polyparasitized groups were not statistically significant. However, children infected with any of the three STH species investigated had higher IL-10 levels than non-parasitized children (geometric means: 0.89 pg/mL vs. 0.74 pg/mL, p = 0.428). Similarly, polyparasitized children had higher IL-10 levels than both monoparasitized and non-parasitized children (1.04 pg/mL, 0.69 pg/mL, and 0.74 pg/mL, respectively, p = 0.481). A significant moderate negative correlation between IL-10 levels and children’s age was found, but no correlations were observed between IL-10 levels and intensity of infection by any of the parasite species investigated.ConclusionsWe found no strong evidence for an association between STH infection and serum IL-10 concentration levels. However, the trends identified here warrant further investigation. Additional research is needed to expand the current understanding of the immune response elicited by STH infections in children living in endemic communities.

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“…Although the number of cases is small and this is not a main objective of this work, our data suggest that contrary to Ascaris tropomyosin, Asc l 5 does not have a significant impact on asthma evolution. However, more studies should be undertaken to address this point, not only in asthma [20] but also to explore the effect of Asc l 5 sensitization on other allergic diseases such as atopic dermatitis, an aspect of ascariasis that have been little investigated [38]. The strength of the IgE response to rAsc l 5 is similar to that observed in other studies against Ascaris tropomyosin or ABA-1 [9,20,39], and greater than that detected for glutathione transferase allergen (Asc l 13) [8,20].…”

Section: Discussionmentioning

confidence: 99%

Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides

Ahumada

Manotas

Zakzuk

et al. 2020

IJMS

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To analyze the impact of Ascaris lumbricoides infection on the pathogenesis and diagnosis of allergic diseases, new allergens should be identified. We report the identification of a new Ascaris lumbricoides allergen, Asc l 5. The aim of this study was to evaluate the physicochemical and immunological features of the Asc l 5 allergen. We constructed an A. lumbricoides cDNA library and Asc l 5 was identified by immunoscreening. After purification, rAsc l 5 was physicochemically characterized. Evaluation of its allergenic activity included determination of Immunoglobulin E (IgE) binding frequency (in two populations: 254 children and 298 all-age subjects), CD203c based-basophil activation tests (BAT) and a passive cutaneous anaphylaxis (PCA) mouse model. We found by amino acid sequence analysis that Asc l 5 belongs to the SXP/RAL-2 protein family of nematodes. rAsc l 5 is a monomeric protein with an alpha-helical folding. IgE sensitization to rAsc l 5 was around 52% in general population; positive BAT rate was 60%. rAsc l 5 induced specific IgE production in mice and a positive PCA reaction. These results show that Asc l 5 has structural and immunological characteristics to be considered as a new allergen from A. lumbricoides.

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Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency

Cited by 3 publications

References 12 publications

The exposome in atopic dermatitis

The exposome in atopic dermatitis

Interleukin-10 and soil-transmitted helminth infections in Honduran children

Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides

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