2012
DOI: 10.1590/s0037-86822012000100027
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Abstract: Visceral leishmaniasis (VL), also known as Kala-azar, is a systemic infection caused by a protozoan (Leishmania) and, in its classic form, is a serious illness associated with malnutrition, anemia, hepatosplenomegaly, infectious processes and coagulopathies. The effect of splenectomy in patients with visceral leishmaniasis is not well defined; however, it is known that the spleen is the largest reservoir of infected cells belonging to the reticulo endothelial system. Therefore, the surgical procedure is an opt… Show more

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Cited by 21 publications
(21 citation statements)
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“…A therapeutic option would be splenectomy 11 ; however, this was not the team's option because the patient was aged 1 year, and it could possibly have several systemic effects. Treatment with immunotherapy and immunochemotherapy 12 could also be useful; however, such therapies were unavailable.…”
Section: Discussionmentioning
confidence: 99%
“…A therapeutic option would be splenectomy 11 ; however, this was not the team's option because the patient was aged 1 year, and it could possibly have several systemic effects. Treatment with immunotherapy and immunochemotherapy 12 could also be useful; however, such therapies were unavailable.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, it has been hypothesized that the liver is mostly a place for initial parasite replication, while spleen functions as a reservoir of parasites, promoting their persistence [13]. Indeed, it has been demonstrated that splenectomy (spleen removal) appears to minimize the effects of severe VL in humans and, sometimes, allow the successful treatment of refractory cases [122].…”
Section: Visceral Manifestationsmentioning
confidence: 99%
“…Most patients with visceral leishmaniasis respond to treatment with antimonials, or with second-line therapeutics, such as pentamidine or amphotericin [4]. However, some patients present multiple relapses, resulting in the failure of conventional therapeutic intervention [5]. In some of these cases, splenectomy can be performed as a final therapeutic attempt [5].…”
Section: Introductionmentioning
confidence: 99%
“…However, some patients present multiple relapses, resulting in the failure of conventional therapeutic intervention [5]. In some of these cases, splenectomy can be performed as a final therapeutic attempt [5]. The literature contains few reports of therapeutic spleen removal in visceral leishmaniasis, and little is known about the mechanism involved in the control of infection obtained via splenectomy [6].…”
Section: Introductionmentioning
confidence: 99%
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