2012
DOI: 10.1590/s0037-86822012000100021
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Abstract: Introduction: Antibiotic-associated diarrhea (AAD) is an important side effect of this specific class of drugs. The objective of this study was to investigate the effect of the use of probiotics in the treatment of AAD. Methods: A group of hospitalized patients, who contracted diarrhea during or after 7 days of suspension of antimicrobial medication, was blindly randomized to receive a standardized diet associated with the use of the probiotics (Lactobacillus casei and Bifidobacterium breve) or its correspondi… Show more

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Cited by 14 publications
(7 citation statements)
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“…However, some studies [26,27] found no positive effect of Lactobacillus casei on the clinical course of diarrhea, such as antibiotic-associated diarrhea. The possible reasons of why probiotics failed to do so are that the dosage, species of probiotics, or antibiotics therapy may reduce the anaerobic bacteria of the intestinal flora.…”
Section: Discussionmentioning
confidence: 99%
“…However, some studies [26,27] found no positive effect of Lactobacillus casei on the clinical course of diarrhea, such as antibiotic-associated diarrhea. The possible reasons of why probiotics failed to do so are that the dosage, species of probiotics, or antibiotics therapy may reduce the anaerobic bacteria of the intestinal flora.…”
Section: Discussionmentioning
confidence: 99%
“…All of the studies were original studies; no long-term follow-up studies were identified or retrieved. Agrawal et al, 2012Irvine et al, 2010Ranganathan et al, 2009Anukam et al, 2010Ishikawa et al, 2011Schunter et al, 2012Bouilly-Gauthier et al, 2010Jenks et al, 2008Sharma et al, 2011Chitapanarux et al, 2010Klarin et al, 2008Shimizu et al, 2009Cimperman et al, 2011Knight et al, 2009Song et al, 2010De los Angeles Pineda et al, 2011Lee et al, 2010Souza and Jorge, 2012Diepenhorst et al, 2011Liu et al, 2010Stadlbauer et al, 2008Eguchiet al, 2011Malaguarnera et al, 2010Steed et al, 2010Fleming et al, 2011Mandel et al, 2010Stephens and Hewett, 2012Frohmader et al, 2010Mangell et al, 2012Tan et al, 2011Fujimori et al, 2009Matthes et al, 2010Tanaka et al, 2012Gao et al, 2010Mittal et al, 2011Tandon et al, 2009Gianotti et al, 2010Morrow et al, 2010Tursi et al, 2010González-Hernández et al, 2012Peguet-Navarro et al, 2008Usami et al, 2011Hemsworth et al, 2012…”
Section: Methodsmentioning
confidence: 99%
“…While evidence supporting therapy of probiotics in treatment of acute diarrheal infection is lacking, and few studies addressing the eff ectiveness of probiotics in treatment of antibiotic-associated diarrhea ( 93 ), there is supporting evidence for the role of probiotics in prevention of acute diarrhea associated with antibiotic use ( 94 ). Th e pooled results among 63 randomized controlled trials across all population, setting, and probiotic types indicated a relative risk reduction of 0.58, with a number needed to treat of 13.…”
Section: Recommendationmentioning
confidence: 99%