2011
DOI: 10.1590/s0037-86822011005000023
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Abstract: IIntroduction: Garlic has a wide range of actions, including antibacterial, antiviral, antifungal, antiprotozoal and anthelmintic actions. This antiparasitic activity has been attributed to allicin, which is the main constituent of garlic. The present study aimed to investigate the in vitro activity of allicin on the tegument of adult Schistosoma mansoni worms using scanning electron microscopy. Methods: Swiss Webster mice were infected with S. mansoni cercariae (100 per mouse) and sacrificed 50 days later to … Show more

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Cited by 39 publications
(24 citation statements)
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“…Generally, if a drug induces tegumental alterations, the onset and precise pattern of these alterations depend on the particular drug and the treatment regimen used (44) . The characteristic features of tegumental damage observed in this study, including destruction of the tegument and erosion and loss of spines, were consistent with those previously described in the literature following in vitro exposure to different antischistosomal agents such as hypericin (45) , allicin (46) , nerolidol (47) , phthalyl thiazole (LpQM-45) (48) , β-lapachone (49) , and DNK (32) . Hence, reductions in worms may be attributed to the tegumental damage observed.…”
Section: Discussionsupporting
confidence: 90%
“…Generally, if a drug induces tegumental alterations, the onset and precise pattern of these alterations depend on the particular drug and the treatment regimen used (44) . The characteristic features of tegumental damage observed in this study, including destruction of the tegument and erosion and loss of spines, were consistent with those previously described in the literature following in vitro exposure to different antischistosomal agents such as hypericin (45) , allicin (46) , nerolidol (47) , phthalyl thiazole (LpQM-45) (48) , β-lapachone (49) , and DNK (32) . Hence, reductions in worms may be attributed to the tegumental damage observed.…”
Section: Discussionsupporting
confidence: 90%
“…Therefore, the tegument is a critically important target for antischistosomal drugs 28 . Electron microscopic analyses, including TEM, have documented damage to the tegument of S. mansoni caused by exposure to synthetic and natural compounds 14 for various antischistosomal prototype compounds 29 .…”
Section: Discussionmentioning
confidence: 99%
“…Recently, in vitro studies for new active compounds against S. mansoni [14][15][16] showed that ROT, a monoterpene found in Mentha species, showed promising antischistosomal properties against adult schistosomes 17,27 .…”
Section: Discussionmentioning
confidence: 99%
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“…O alho (Allium sativum) tem sido utilizado como tratamento de diversas doenças desde a antiguidade (Mota et al, 2005) e alguns estudos mais atuais têm encontrado resultados positivos da sua ação antibacteriana, antifúngica, antiviral, antiprotozoário e anti-helmíntico (Venturoso et al, 2011;Lima et al, 2011;Mantawy et al, 2011). Os resultados apresentados no presente estudo trouxeram evidências de que o alho apresenta efeito inibitório sob o desenvolvimento microbiano, fato também comprovado por outros estudos (Venturoso et al, 2011;Silva et al, 2012 ;Cohain, 2010;Casella et al, 2012).…”
Section: Discussionunclassified