Leishmaniose visceral: estudo retrospectivo de fatores associados à letalidade

Alvarenga, Daniel; Escalda, Patrícia Maria Fonseca; Costa, Alexandre Sylvio Vieira da; Monreal, Maria Tereza Ferreira Duenhas

doi:10.1590/s0037-86822010000200017

Cited by 75 publications

(87 citation statements)

References 9 publications

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“…This result may be related to the incomplete development of the immune system in the children the comorbidity of HVL with chronic diseases, and the decline of the immune system in the elderly (33) (34) (35) (36) . The higher incidence in males is consistent with the literature (33) (34) (36) (37) . The mortality rate was also higher in males and those aged 60 and older, which may also be related to immune factors and complications from pre-existing conditions.…”

Section: Discussionsupporting

confidence: 93%

Occurrence of Lutzomyia longipalpis andhuman and canine cases of visceral leishmaniasis and evaluation of their expansion in the Northwest region of the State of São Paulo, Brazil

Oliveira

Guirado

Dibo

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Section: Discussionsupporting

confidence: 93%

Occurrence of Lutzomyia longipalpis andhuman and canine cases of visceral leishmaniasis and evaluation of their expansion in the Northwest region of the State of São Paulo, Brazil

Oliveira

Guirado

Dibo

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…Many studies have demonstrated multiple causes of death and have identifi ed clinical risk factors as important predictive markers 9,10,20,21 . The host immunological response to the parasite is certainly a major clinical determinant in VL 10,22 .…”

Section: Discussionmentioning

confidence: 99%

Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

Gama

Gomes

Sílveira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):741-745, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0203-2013 INTRODUCTION ABSTRACT Introduction:The relationship between severe clinical manifestations of visceral leishmaniasis (VL) and immune response profi les has not yet been clarifi ed, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profi les and the presence of immunological markers associated with clinical manifestations and, particularly, signs of severity, as defi ned in a protocol drafted by the Ministry of Health (Brazil). Methods: We conducted a prospective, descriptive study between May 2008 and December 2009. This study was based on an assessment of all pediatric patients with VL who were observed in a reference hospital in Maranhão. Results: Among 27 children, 55.5% presented with more than one sign of severity or warning sign. Patients without signs of severity or warning signs and patients with only one warning sign had the highest interferon-gamma (IFN-γ) levels, although their interleukin 10 (IL-10) levels were also elevated. In contrast, patients with the features of severe disease had the lowest IFN-γ levels. Three patients who presented with more than two signs of severe disease died; these patients had undetectable interleukin 2 (IL-2) and IFN-γ levels and low IL-10 levels, which varied between 0 and 36.8pg/mL. Conclusions: Our results showed that disease severity was associated with low IFN-γ levels and elevated IL-10 levels. However, further studies with larger samples are needed to better characterize the relationship between disease severity and cytokine levels, with the aim of identifying immunological markers of active-disease severity.

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“…Ao se percorrer os eixos rodoviários e ferroviários de São Paulo, observam-se padrões semelhantes de expansão urbana e mobilidade da população em outras cidades do interior paulista, como Araçatuba-SP, Presidente Prudente-SP e Dracena-SP. 16,17 O predomínio de casos masculinos, como descrito em outros trabalhos disponíveis na literatura, 18,19 sugere que homens estariam mais expostos ao vetor, provavelmente em função de desempenharem atividades ocupacionais e comportamentais mais próximas à fonte de infecção. 20 Considerando-se que cerca de 40% dos casos foram registrados em crianças com menos de 10 anos e que esse segmento etário corresponde a menos de 15% da população de Bauru-SP, fica evidente a alta carga de morbidade nessa faixa etária.…”

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Epidemiologia da leishmaniose visceral em Bauru, São Paulo, no período de 2004 a 2012: um estudo descritivo

Ortiz

Anversa

2015

Epidemiol. Serv. Saúde

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ResumoObjetivo: descrever as características epidemiológicas dos casos de leishmaniose visceral (LV) notificados no município de Bauru, estado de São Paulo, Brasil, no período de 2004 a 2012. Métodos: estudo descritivo, com dados obtidos do Sistema de Informação de Agravos de Notificação (Sinan), gerido pela Secretaria Municipal de Saúde. Resultados: no período estudado, foram notificados 381 casos de LV, distribuídos em 100 (28,6%) bairros da cidade; 61,7% dos casos pertenciam ao sexo masculino; 43,8% eram crianças com idade ≤10 anos; 98,4% eram moradores da zona urbana; a taxa de coinfecção LV/HIV encontrada foi de 9,2%; e 8,1% dos casos evoluíram para óbito. Conclusão: entre os casos, predominaram homens, residentes na área urbana, em bairros da periferia e com baixa escolaridade; a diversificação dessas características aponta para a necessidade de otimizar as ações de vigilância e controle da doença.Palavras-chave: Leishmaniose; Leishmaniose Visceral; Sistemas de Informação; Epidemiologia Descritiva. Bauru, state of São Paulo, Brazil, 2004 Abstract Objective: to describe the epidemiological aspects of visceral leishmaniasis (VL) cases reported in the municipality of

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Leishmaniose visceral: estudo retrospectivo de fatores associados à letalidade

Abstract: The results suggest that the prognosis becomes poor when associated with the presence of comorbidities, and that the treatment needs to be carefully administered to minimize mortality.

Cited by 75 publications

References 9 publications

Occurrence of Lutzomyia longipalpis andhuman and canine cases of visceral leishmaniasis and evaluation of their expansion in the Northwest region of the State of São Paulo, Brazil

Occurrence of Lutzomyia longipalpis andhuman and canine cases of visceral leishmaniasis and evaluation of their expansion in the Northwest region of the State of São Paulo, Brazil

Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

Epidemiologia da leishmaniose visceral em Bauru, São Paulo, no período de 2004 a 2012: um estudo descritivo

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