2010
DOI: 10.1590/s0037-86822010000200015
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Abstract: Artigo/Article Reações adversas em pacientes com doença de Chagas tratados com benzonidazol, no Estado do Ceará ABSTRACTIntroduction: Chagas disease is caused by Trypanosoma cruzi and treated with benznidazole (BNZ). This drug has the troublesome features of presenting partial effectiveness and high toxicity ranging from hypersensitivity reactions to medullary aplasia. The objective here was to describe and evaluate the occurrence of adverse reactions in Chagas disease patients treated with benznidazole in For… Show more

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Cited by 27 publications
(29 citation statements)
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“…However, the variables associated with ADRs included in our prediction model were also found by others to be related to ADRs due to BZN (19,45). The percentage of BZN treatment interruption described by us is higher than the percentage observed by Viotti et al (19), but it is similar to the percentage of interruption described for other studies conducted in Brazil (21).…”
Section: Discussionsupporting
confidence: 85%
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“…However, the variables associated with ADRs included in our prediction model were also found by others to be related to ADRs due to BZN (19,45). The percentage of BZN treatment interruption described by us is higher than the percentage observed by Viotti et al (19), but it is similar to the percentage of interruption described for other studies conducted in Brazil (21).…”
Section: Discussionsupporting
confidence: 85%
“…However, adverse drug reactions (ADRs) occur in 30% to 87% of the patients treated with BZN (19-21), and 12% to 29% of patients fail to complete their full course of treatment (19-21). Therefore, the development of tools to identify patients with high probabilities of developing ADRs to BZN is highly desirable, as this strategy would improve compliance to BZN treatment and minimize complications (21,22).Logistic regression (LR) is a method often used to predict outcomes in health studies (23,24), and it can be used to identify which variables are associated with the occurrence of ADRs to BZN. Therefore, the present study aimed to identify predictive factors for ADRs and ADRs that caused BZN treatment to be discontinued among patients with chronic Chagas disease treated with BZN.…”
mentioning
confidence: 99%
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“…Resultados semelhantes também foram encontrados também por Pontes et al (2010) e Correia (2014). Os resultados referentes à renda familiar e à baixa escolaridade comprovam que os pacientes com DC possuem pouco acesso a informações e ao serviço de saúde, o que leva a uma maior importância do acompanhamento desses pacientes por um serviço público especializado na busca da sua melhoria de qualidade de vida 12,19 . A evidência de DC em municípios localizado na região do Vale do Jaguaribe cearense há tempo vem sendo objeto de estudos, como de creatinina, acima dos valores de referência e superiores às do estudo em questão.…”
Section: Parâmetros Bioquímicos E Hematológicosunclassified