Analysis of GB virus C infection among HIV-HCV coinfected patients

Barbosa, Aline de Jesus; Baggio-Zappia, Giovana Lotici; Dobo, Cristine; Alves-Sousa, Viviane Kelly; Lanzara, G; Silva, Ismael Dale Cotrim Guerreiro da; Lanzoni, Valéria Pereira; Granato, Celso Francisco Hernandes

doi:10.1590/s0037-86822009000500021

Cited by 8 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 5'-untranslated region of GBV-C was chosen because it is a conserved region among all viral isolates around the world. A total of 119 sequences available in GenBank were aligned in Sequencher 4.5 software (Gene Codes Corporation) to design the primers used for qPCR as previously described (Barbosa et al 2009). Samples were tested for the presence of GBV-C E2 antibodies using a commercial enzymatic immunoassay (Roche Diagnostics GmbH).…”

Section: Patients Materials and Methodsmentioning

confidence: 99%

Influence of GB virus C on IFN-γ and IL-2 production and CD38 expression in T lymphocytes from chronically HIV-infected and HIV-HCV-co-infected patients

Baggio-Zappia

Barbosa

Brunialti³

et al. 2011

Mem. Inst. Oswaldo Cruz

Self Cite

View full text Add to dashboard Cite

Section: Patients Materials and Methodsmentioning

confidence: 99%

Influence of GB virus C on IFN-γ and IL-2 production and CD38 expression in T lymphocytes from chronically HIV-infected and HIV-HCV-co-infected patients

Baggio-Zappia

Barbosa

Brunialti³

et al. 2011

Mem. Inst. Oswaldo Cruz

Self Cite

View full text Add to dashboard Cite

“…Although infection with GBV-C is common in the HIV-1 infected population, it has not been associated with chronic disease or affect the clinical course of hepatitis A, B, or C infection(s) [8]. Over the past several years a number of studies have found GBV-C to exert a favorable impact on the course of HIV-1 [9], [10], [11], [12], [13] or HCV infections [14], [15] with a lower mortality rate, slower progression to AIDS, and longer survival once AIDS has developed. Others studies have failed to demonstrate a similar effect [16], [17], [18], [19].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

et al. 2011

View full text Add to dashboard Cite

BackgroundThe results of previous studies elsewhere have indicated that GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus type 1 (HIV-1) due to similar transmission routes of both viruses. The aim of this study was to determine the prevalence, incidence density and genotypic characteristics of GBV-C in this population.Methodology/Principal FindingsThe study population included 233 patients from a cohort primarily comprised of homosexual men recently infected with HIV-1 in São Paulo, Brazil. The presence of GBV-C RNA was determined in plasma samples by reverse transcriptase-nested polymerase chain reaction and quantified by real-time PCR. GBV-C genotypes were determined by direct sequencing. HIV viral load, CD4+ T lymphocyte and CD8+ T lymphocyte count were also tested in all patients. The overall prevalence of GBV-C infection was 0.23 (95% CI: 0.18 to 0.29) in the study group. There was no significant difference between patients with and without GBV-C infection and Glycoprotein E2 antibody presence regarding age, sex, HIV-1 viral load, CD4+ and CD8+T cell counts and treatment with antiretroviral drugs. An inverse correlation was observed between GBV-C and HIV-1 loads at enrollment and after one year. Also, a positive but not significant correlation was observed between GBV-C load and CD4+ T lymphocyte. Phylogenetic analysis of the GBV-C isolates revealed the presence of genotype 1 and genotype 2, these sub classified into subtype 2a and 2b.Conclusion/SignificanceGBV-C infection is common in recently HIV -1 infected patients in Sao Paulo, Brazil and the predominant genotype is 2b. This study provides the first report of the GBV-C prevalence at the time of diagnosis of HIV-1 and the incidence density of GBV-C infection in one year.

show abstract

“…Sabe-se que a via parenteral, principalmente para a hepatite C, e a sexual, mais importante na hepatite B, são altamente efetivas para a transmissão das mesmas, embora 30 a 35% dos casos de hepatite B e até 40% dos casos de hepatite C, não possuam uma via de transmissão bem determinada 84,85,86 .…”

Section: -Determinação Da Contagem De Linfócitos T Cd4+unclassified

A influência do vírus da hepatite G (GBV-C) na evolução da infecção pelo HIV em mulheres

Campos¹

View full text Add to dashboard Cite

show abstract

Analysis of GB virus C infection among HIV-HCV coinfected patients

Cited by 8 publications

References 17 publications

Influence of GB virus C on IFN-γ and IL-2 production and CD38 expression in T lymphocytes from chronically HIV-infected and HIV-HCV-co-infected patients

Influence of GB virus C on IFN-γ and IL-2 production and CD38 expression in T lymphocytes from chronically HIV-infected and HIV-HCV-co-infected patients

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

A influência do vírus da hepatite G (GBV-C) na evolução da infecção pelo HIV em mulheres

Contact Info

Product

Resources

About