Is an increased body mass index associated with a risk of cutaneous leishmaniasis?

Cunha, Daniel Ferreira da; Cunha, Selma Freire de Carvalho da; Nunes, Adriana Guimarães; Silva‐Vergara, Mario León

doi:10.1590/s0037-86822009000500004

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…None of the patients or controls was underweight. However, 50.0% of patients and 40.5% of controls were overweight or obese and similar results were presented by Ferreira da Cunha et al [60]. Overweight and obesity is not an indication that the patients have a better nutritional status; they may have micronutrient deficiencies and an impaired immunity associated with the consumption of imbalanced diets [61,62].…”

Section: Discussionsupporting

confidence: 59%

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Lazarte¹,

Alegre²,

Rojas³

et al. 2013

FNS

View full text Add to dashboard Cite

Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of healthy controls and reference values. Results showed no significant differences in most nutrient intake or anthropometrics between patients and controls. However, serum zinc level of patients (80 μg/dl) was significantly lower (P < 0.001) than in controls (85 μg/dl), likely explained by the presence of leishmaniasis. The median serum zinc level in both groups was below the reference values, even though their median zinc intake met the zinc recommendations from WHO. Consequently, besides the presence of leishmaniasis, serum zinc levels may be compromised by inhibitory components in their diet, such as phytates, as it is shown by the molar ratio phytate:zinc (Phy:Zn) that was between 11 and 19, while 15 is the level said to compromise zinc status. There were significant (P < 0.05) negative correlations between serum zinc and Phy:Zn, for patients (r = −0.413) and controls (r = −0.410). In conclusion this study shows that patients with CL in Chapare, Bolivia had low serum zinc levels due to the leishmaniasis per se and the decreased zinc bioavailability in their diet. CL infection was not in direct association with the nutritional status indicated by the anthropometric or dietary assessments. However, dietary intake showed 5 essential nutrients below the nutrient recommendation in both groups.

show abstract

Section: Discussionsupporting

confidence: 59%

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Lazarte¹,

Alegre²,

Rojas³

et al. 2013

FNS

View full text Add to dashboard Cite

show abstract

“…It is suggested that toxoplasmosis associate with obesity by alteration of inflammatory fat distribution as organisms change and reside in fatty tissues [ 38 ]. Men and women with cutaneous leishmaniasis presented higher body mass index than the controls [ 39 ]. Association between overweight and asthma have been found among females, persistent asthma associated with high BMI throughout childhood [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Computational analyses of obesity associated loci generated by genome-wide association studies

et al. 2018

View full text Add to dashboard Cite

ObjectivesGenome-wide association studies (GWASs) have discovered associations of numerous SNPs and genes with obesity. However, the underlying molecular mechanisms through which these SNPs and genes affect the predisposition to obesity remain not fully understood. Aims of our study are to comprehensively characterize obesity GWAS SNPs and genes through computational approaches.MethodsFor obesity GWAS identified SNPs, functional annotation, effects on miRNAs binding and impact on protein phosphorylation were performed via RegulomeDB and 3DSNP, miRNASNP, and the PhosSNP 1.0 database, respectively. For obesity associated genes, protein-protein interaction network construction, gene ontology and pathway enrichment analyses were performed by STRING, PANTHER and STRING, respectively.ResultsA total of 445 SNPs are significantly associated with obesity related phenotypes at threshold P < 5×10−8. A number of SNPs were eQTLs for obesity associated genes, some SNPs located at binding sites of obesity related transcription factors. SNPs that might affect miRNAs binding and protein phosphorylation were identified. Protein-protein interaction network analysis identified the highly-interconnected “hub” genes. Obesity associated genes mainly involved in metabolic process and catalytic activity, and significantly enriched in 15 signal pathways.ConclusionsOur results provided the targets for follow-up experimental testing and further shed new light on obesity pathophysiology.

show abstract

“…Overweight and obesity are well-known risk factors for infections [18]. Cross-sectional studies have associated obesity with a higher risk of cutaneous leishmaniasis [CL] and failure to respond to therapy [19,20]. Models of diet-induced obesity in mice were used to demonstrate a higher susceptibility to CL and visceral leishmaniasis (VL), which was accompanied by systemic inflammation [21,22].…”

Section: Introductionmentioning

confidence: 99%

Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis

Araújo,

Moreira,

Mesquita

et al. 2023

Immunology

View full text Add to dashboard Cite

Under perturbing conditions such as infection with Leishmania, a protozoan parasite living within the phagosomes in mammalian macrophages, cellular and organellar structures, and metabolism are dynamically regulated for neutralizing the pressure of parasitism. However, how modulations of the host cell metabolic pathways support Leishmania infection remains unknown. Herein, we report that lipid accumulation heightens the susceptibility of mice to L. donovani infection and promotes resistance to first‐line anti‐leishmanial drugs. Despite being pro‐inflammatory, the in vitro generated uninfected lipid‐laden macrophages (LLMs) or adipose‐tissue macrophages (ATMs) display lower levels of reactive oxygen and nitrogen species. Upon infection, LLMs secrete higher IL‐10 and lower IL‐12p70 cytokines, inhibiting CD4+ T cell activation and Th1 response suggesting a key modulatory role for intramacrophage lipid accumulation in anti‐leishmanial host defence. We, therefore, examined this causal relationship between lipids and immunomodulation using an in vivo high‐fat diet (HFD) mouse model. HFD increased the susceptibility to L. donovani infection accompanied by a defective CD4+ Th1 and CD8+ T cell response. The white adipose tissue of HFD mice displays increased susceptibility to L. donovani infection with the preferential infection of F4/80+CD11b+CD11c+ macrophages with higher levels of neutral lipids reserve. The HFD increased resistance to a first‐line anti‐leishmanial drug associated with a defective adaptive immune response. These data demonstrate that the accumulation of neutral lipids contributes to susceptibility to visceral leishmaniasis hindering host‐protective immune response and reducing the efficacy of antiparasitic drug therapies.

show abstract

Is an increased body mass index associated with a risk of cutaneous leishmaniasis?

Cited by 6 publications

References 10 publications

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Computational analyses of obesity associated loci generated by genome-wide association studies

Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis

Contact Info

Product

Resources

About