2008
DOI: 10.1590/s0037-86822008000400022
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Abstract: Vinte e cinco camundongos infectados com Leishmania amazonensis foram tratados com antimoniato de N-metil glucamina e miltefosina oral. Critérios: medidas das patas, pesquisa de amastigotas e culturas após-tratamento. Miltefosina: 2,43mm e glucamina 3,46mm (p=0,05). Miltefosina: esfregaços e culturas negativos. Glucamina: 2 esfregaços positivos e culturas positivas (p<0,05). Concluímos que miltefosina foi semelhante à glucamina.

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Cited by 20 publications
(8 citation statements)
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“…It also appears to be safe for the treatment of CL caused by Leishmania braziliensis [29,30], L. (Viannia) guyanensis [31] and L. amazonensis [30], among other Leishmania species [8], with the advantage of being less toxic or at least relatively well tolerated and healing lesions in a shorter period of time [29][30][31]. Also, oral miltefosine administered in mice seemed to have similar if not greater effect than N-methyl glucamine in the experimental treatment of cutaneous leishmaniasis caused by L. amazonensis [32]. In the present study, miltefosine was chosen because it presents advantages in its oral administration, favouring treatment compliance and convenience for the patient, being a safe and economically viable therapeutic option [30].…”
Section: Discussionmentioning
confidence: 99%
“…It also appears to be safe for the treatment of CL caused by Leishmania braziliensis [29,30], L. (Viannia) guyanensis [31] and L. amazonensis [30], among other Leishmania species [8], with the advantage of being less toxic or at least relatively well tolerated and healing lesions in a shorter period of time [29][30][31]. Also, oral miltefosine administered in mice seemed to have similar if not greater effect than N-methyl glucamine in the experimental treatment of cutaneous leishmaniasis caused by L. amazonensis [32]. In the present study, miltefosine was chosen because it presents advantages in its oral administration, favouring treatment compliance and convenience for the patient, being a safe and economically viable therapeutic option [30].…”
Section: Discussionmentioning
confidence: 99%
“…We chose not to use N-methyl glucamine (the fi rst line of treatment for Leishmania infection), since we know that miltefosine has the same effi cacy in Leishmania amazonensis 4 , and our goal was to test whether a combination of oral drugs would provide a better response to treatment. When we analyzed the paw diameters, we adopted a signifi cance (alpha) level of 5%, and both treatment groups (M, M + P) were signifi cantly smaller (p < 0.05) than group (C) on D6 and D12.…”
Section: Analysis Of Culturesmentioning
confidence: 99%
“…All fi rst and second drug choices, including miltefosine, have high toxicity, require parenteral use, have high rates of relapse and drug resistance, and ultimately lead to treatment failure, especially in immunocompromised patients who desperately require new therapies 3 . Miltefosine (hexadecylphosphocholine) is an alkylphosphocholine, originally developed for the treatment of cancer, which was discovered to possess antifungal, antiamoebic, and leishmanicidal activity 4,5 . The drug exerts its cytotoxic effect by interfering with the metabolism of membrane phospholipids, altering the composition, permeability, stability, and fluidity of the cell membrane, subsequently inducing apoptos is 3,6 .…”
mentioning
confidence: 99%
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“…Further, amphotericin B and pentamidine are second- and third-choice drugs, respectively, which have been used when facing contraindications, intolerance or parasite resistance to antimonials. However, these drugs used in the chemotherapy of leishmaniasis have several side effects, and treatment failure and cases of relapse have been reported [2,3]. …”
Section: Introductionmentioning
confidence: 99%