Anticorpos anti-Leptospira em pacientes de Mato Grosso do Sul com suspeita clínica de dengue ou hepatite viral

Abstract

In view of the lack of clinical and epidemiological data on human leptospirosis in the State of Mato Grosso do Sul, and the possibility of confounding it with other diseases, sera from patients with a preliminary clinical suspicion of dengue or viral hepatitis but without laboratory confirmation were examined by means of microscopic seroagglutination techniques for leptospirosis. The seroreactivity rates among the samples with clinically suspected dengue or viral hepatitis were 15.9% and 9%. The most frequent serovar was Hurstbridge (70.4%) and the serovar with the highest titer was Canicola (1:51,200). No association was found between seropositivity and the patients sex, age or occupation. This study demonstrated that, although the present notifications of leptospirosis cases in Mato Grosso do Sul are negligible, the prevalence of antibodies was high in the groups investigated. Therefore, the hypothesis that there is undernotification of human leptospirosis cases in this State and difficulties in the differential diagnosis between dengue and viral hepatitis should be considered.

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

“…However, Behera, et al, considered a patient who was positive for the ELISA to be a case of co-infection, showing anti-dengue and antiLeptospira antibodies (27). Thirty-five patients remained without a specific laboratory diagnosis, suggesting that they had been infected by other (28)(29)(30).…”

Maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management

“…These include other arboviruses, such as the flavivirus Saint Louis Encephalitis [11], Chikungunya fever [12, 13], Zika fever [14], leptospirosis [15, 16], visceral leishmaniasis [17], and malaria [18]. …”

Um modelo bayesiano para investigação de sobremortalidade durante epidemia de dengue na Região Metropolitana do Rio de Janeiro, Brasil, 2007-2008

“…Considerando ainda a dificuldade no diagnóstico desse agravo, tanto pela sintomatologia inespecífica e similaridade do quadro clínico com outras doenças infecciosas 5,6,7 quanto pelo rigoroso critério de definição de caso utilizado pela OMS 8 , pelas dificuldades no acesso à confirmação laboratorial 6 e pela superposição da sazonalidade do dengue e de outros agravos que fazem parte do seu diagnóstico diferencial 7 , pode-se levantar a hipótese plausível da ocorrência de óbitos não registrados como dengue.…”