Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae

Simas, Naomi Kato; Lima, Elisângela da Costa; Kuster, Ricardo Machado; Lage, Celso Luiz Salgueiro; Filho, Alfredo Martins de Oliveira

doi:10.1590/s0037-86822007000400006

Cited by 29 publications

(31 citation statements)

References 7 publications

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“…The black pepper (P. nigrum L.) is a perennial woody vine species largely traded worlwide as condiment, medicinal purposes, and other uses such as as phytolarvicides in control of dengue insect (Aedes aegypti) (Simas et al, 2007;Grzybowski et al, 2012). Despite the high number of catalogued varieties (around 51) by Mathew et al (2001) in India, in Brazil, the production relies on the Bragantina variety, mainly in pepper nurseries of northern Espírito Santo state.…”

Section: Introductionmentioning

confidence: 99%

Rooting responses of black pepper (Piper nigrum cv. Bragantina) as affected by chemical, physical and microbiological properties of substrates and auxin

Freire¹,

Schmildt²,

Lopes³

et al. 2017

Aust J Crop Sci

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The quality of the root system in stem cuttings of Piper nigrum is highly associated with the induction of adventitious roots by means of auxins and type of substrates. The objective of this study was to evaluate the rooting of P. nigrum cv. Bragantina cuttings treated or not with indole-3-butyric acid (IBA) in different substrates. The experiment was conducted in a randomized block design following a factorial 2 x 11 scheme (IBA -0 and 4000 mg kg -1 in talc and 11 substrates), with four repetitions of 16 cuttings each. The auxin increased rooting and improved the quality of the root system. The substrates evaluated presented diverse physical, chemical and microbiological characteristics, interfering significantly in the rooting responses. Substrates (d) -soil + limestone + single superphosphate + potassium chloride + chicken manure and (i) -soil + coffee straw + limestone + single superphosphate are the ones recommended for rooting of pepper cv. Bragantina.

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Section: Introductionmentioning

confidence: 99%

Rooting responses of black pepper (Piper nigrum cv. Bragantina) as affected by chemical, physical and microbiological properties of substrates and auxin

Freire¹,

Schmildt²,

Lopes³

et al. 2017

Aust J Crop Sci

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“…The ethanol crude extract from the unripe P. nigrum fruits has previously been tested against the 3 rd instar larvae of A. aegypti that are resistant to the pyrethroid cypermethrin with an LC50 value of 0.98 μg/mL (Simas et al, 2007). The ethanolic extracts of three other species of Piperaceae were tested against the A. aegypti 4 th instar larvae, and the LC50 results were higher than those found for P. nigrum.…”

Section: Aedes Aegypti Larvae Lethality Bioassays and Chromatographicmentioning

confidence: 99%

The combined action of phytolarvicides for the control of dengue fever vector, Aedes aegypti

Grzybowski¹,

Tiboni²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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Amongst other botanical sources, Annona muricata L., Annonaceae, seeds and Piper nigrum L., Piperaceae, fruits are particularly enriched with acetogenins and piperine-related amides, respectively. These crude ethanolic extracts are potent bioactives that can kill Aedes aegypti larvae (dengue fever mosquito). A. muricata displayed a 93.48 μg/mL LC50 and P. nigrum an 1.84 μg/mL LC50. An uncommon pharmacognostical/toxicological approach was used, namely different combinations of both extracts to achieve an improved lethal effect on the larvae. The independence test (χ²) was utilized to evaluate the combination of the two crude extracts. All of the tested combinations behaved synergistically and these novel results were attributed to the completely different biochemical mechanisms of the differentiated chemical substances that were present in the two botanical sources. Besides the two above selected plants, Melia azedarach L., Meliaceae, Origanum vulgare L., Lamiaceae, and Ilex paraguariensis A. St.-Hil., Aquifoliaceae, in order of decreasing toxicity, may also be sought as potential extracts for the sake of synergic combinations.

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“…However, the mentioned reports have been developed on Asian species so that it is unable to correlate published results of insecticidal activity with the present findings. Some examples about biological activity of Piper are found published on literature [7][8][23][24][25][26] . Regarding to Piper plants studied here, reports on their biological activity have demonstrated to be almost inexistent.…”

Section: Multivariate Analysismentioning

confidence: 99%

FINGERPRINT ANALYSIS OF UNFRACTIONATED Piper PLANT EXTRACTS BY HPLC-UV-DAD COUPLED WITH CHEMOMETRIC METHODS

Bernal

Delgado

Cuca

2012

J. Chil. Chem. Soc.

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ABSTRACT23 crude ethanolic extracts of Piper plants were analyzed by combining HPLC fingerprints and chemometric methods including principal component analysis (PCA), hierarchical clustering analysis (HCA) and parallel factor analysis (PARAFAC). All statistical analysis were carried out both with and without previous preprocessing by counting with alignment of the fingerprints by correlation optimized warping (COW) and several normalization methods. Normalization processes of autoscaling, range scaling and vast scaling resulted to be the better offering the most relevant information. Both direct two-way methods (PCA and HCA) and HCA after data minimization employing a three-way method (PARAFAC) were demonstrated to be useful in the establishment of chemical composition relationships among Piper samples, and resulting in agreement with phylogenic relationships previously reported in literature to some Piper species.

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Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae

Abstract: Fractionation of

Cited by 29 publications

References 7 publications

Rooting responses of black pepper (Piper nigrum cv. Bragantina) as affected by chemical, physical and microbiological properties of substrates and auxin

Rooting responses of black pepper (Piper nigrum cv. Bragantina) as affected by chemical, physical and microbiological properties of substrates and auxin

The combined action of phytolarvicides for the control of dengue fever vector, Aedes aegypti

FINGERPRINT ANALYSIS OF UNFRACTIONATED Piper PLANT EXTRACTS BY HPLC-UV-DAD COUPLED WITH CHEMOMETRIC METHODS

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