2005
DOI: 10.1590/s0037-86822005000100008
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Abstract: RESUMO Investigamos em portadores de esquistossomose hepatoesplênica após esplenectomia com ou sem auto-implante esplênico: índice de aderência, produção de superóxido (SP) e de TNF-α em monócitos, tratados ou não com tuftsina. Avaliamos três grupos: voluntários sadios CG (grupo controle) (n=12); esplenectomizados com auto-implante AG (n=18) e esplenectomizados sem auto-implante WAG (n=9

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Cited by 5 publications
(3 citation statements)
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References 21 publications
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“…Considering that patients suffering from different diseases who underwent splenectomy are at risk of overwhelming post splenectomy severe infection 6 it is important to consider that patient carriers of hepatosplenic schistosomiasis mansoni who undergo this surgical procedure for decompressing the portal pressure should remain with residual spleen tissue; this is specially true for children. We have shown that several functions of monocytes in patients from the study group remain similar to those from control individuals without S. mansoni infection 5,7,8 . It may be important to consider that these patients, at long term follow-up are also presenting improvement in the liver function, this is again true even for those who persisted with residual infection, and have received a second medical treatment with praziquantel 23 .…”
Section: Discussionmentioning
confidence: 66%
See 1 more Smart Citation
“…Considering that patients suffering from different diseases who underwent splenectomy are at risk of overwhelming post splenectomy severe infection 6 it is important to consider that patient carriers of hepatosplenic schistosomiasis mansoni who undergo this surgical procedure for decompressing the portal pressure should remain with residual spleen tissue; this is specially true for children. We have shown that several functions of monocytes in patients from the study group remain similar to those from control individuals without S. mansoni infection 5,7,8 . It may be important to consider that these patients, at long term follow-up are also presenting improvement in the liver function, this is again true even for those who persisted with residual infection, and have received a second medical treatment with praziquantel 23 .…”
Section: Discussionmentioning
confidence: 66%
“…The risk of severe infection is an important health problem in splenectomized patients, greater in children, but still present in adults with the overall rate of 7.0 per 100 persons-years (95% confidence interval, 6.30 -7.78) 6 . The immune protective effects of the splenosis after spleen tissue auto implantation in children with mansoni schistosomiasis who underwent splenectomy has been studied, but although several studies 7,8 have given support to the concept that the maintenance of residual immune function after auto implantation of spleen tissue is beneficial against overwhelming postoperative severe infection, the subject is still matter of controversy when the monocytes of these patients are submitted to stress 8 . The fundamental initiating factor in portal hypertension of patients with mansoni schistosomiasis is an increase in resistance to portal venous flow.…”
Section: Introductionmentioning
confidence: 99%
“…O efeito imune de proteção da esplenose após autoimplante de tecido esplênico no omento maior em crianças portadoras de esquistossomose mansônica que se submeteram a esplenectomia tem sido estudado. Todavia, embora vários estudos 5,7,8 emprestem suporte ao conceito da manutenção da função imune esplênica após esse procedimento, o assunto ainda é objeto de controvérsia quando os monócitos desses pacientes são submetidos ao stress 8 .…”
Section: Introductionunclassified