Comparative clinical and ultrasound study of egg-negative and egg-positive individuals from Schistosoma mansoni low morbidity endemic areas, and hospitalized patients with hepatosplenic disease

Magalhães, Télcia Vasconcelos Barros; Gazzinelli, Giovanni; Alvarez, Maria Carolina B; Silva, F. C. Lima E; Fraga, Lucia Alves Oliveira; Silveira, Alda Maria Soares; Gazzinelli, Andréa; Bethony, Jeffrey M.; LoVerde, Philip T.; Caldas, Iramaya Rodrigues; Corrêa-Oliveira, Rodrigo; Prata, Áluízio

doi:10.1590/s0037-86822005000100007

Cited by 12 publications

(4 citation statements)

References 12 publications

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“…However, this span of time was not sufficient to reduce the spleen size. These results tend to confirm that the chemotherapy favors involution of liver fibrosis (12,34). In addition, our study confirmed that a decrease in worm burden favors the reversal of liver fibrosis.…”

Section: Discussionsupporting

confidence: 85%

“…The direct evaluation of the intensity of hepatic fibrosis in large cohorts may be carried out by abdominal ultrasound examination, a technique that is noninvasive, safe, reliable, and relatively inexpensive. Moreover, there are several criteria available for grading the severity of the disease based on the determination of liver and spleen parameters (1,12,32,34,36). In the present study we evaluated the morbidity (by ultrasound analysis) and the cel-lular immune response of schistosomiasis patients before and one year after treatment with praziquantel.…”

mentioning

confidence: 99%

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Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni

Martins-Leite

Gazzinelli

Alves-Oliveira

et al. 2008

Antimicrob Agents Chemother

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The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultrasound examinations conducted on, volunteers infected with Schistosoma mansoni and living in an area where the disease is endemic, both prior to and one year after treatment with praziquantel. Subjects were classified into groups according to the level of pathology (i.e., absent, incipient, moderate, or severe fibrosis). PBMCs were stimulated with schistosome soluble egg antigens (SEA), and the levels of production of the cytokines gamma interferon (IFN-␥), tumor necrosis factor alpha, transforming growth factor ␤, and interleukin-4 (IL-4), IL-10, and IL-13 were determined. The chemotherapy was effective in reducing morbidity, particularly for individuals presenting with severe fibrosis. When levels of cytokine production in posttreatment PBMC cultures stimulated by SEA were categorized as low or high, significant differences in the distribution of IL-13 levels between groups presenting with or not presenting with fibrosis were established. Comparison of pre-and posttreatment SEA-induced cytokine levels in individuals who had experienced no change in the grade of fibrosis following chemotherapy revealed that the level of IFN-␥ decreased in subjects with fibrosis whereas that of IL-10 decreased in individuals with and without fibrosis. The data suggest that chemotherapy is effective in reducing the morbidity of the disease and that the level of IL-13 may be a useful indicator of the persistence of fibrosis following treatment.

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni

Martins-Leite

Gazzinelli

Alves-Oliveira

et al. 2008

Antimicrob Agents Chemother

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“…Liver size, portal vein diameter, thickness of the walls of the central and peripheral portal branches, spleen size, and splenic and mesenteric vein diameters were assessed using a conventional portable ultrasound instrument (ultrasonic diagnostic instrument model EUB-200; Hitachi, Tokyo, Japan). Periportal thicknesses were evaluated according to the established criteria for the classification of hepatic fibrosis, with some modifications (1,25). In this classification, the degree of fibrosis was determined from the central and peripheral echogenic periportal thickness of the liver portal system.…”

Section: Methodsmentioning

confidence: 99%

Cytokine Production Associated with Periportal Fibrosis during Chronic Schistosomiasis Mansoni in Humans

et al. 2006

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Volunteers living in an area where schistosomiasis mansoni is endemic were subjected to ultrasound examination and classified into groups according to the levels of fibrosis diagnosed, namely, absence of indications of fibrosis (group 0), incipient fibrosis (group 1), and moderate/severe fibrosis (group 2). Peripheral blood mononuclear cells (PBMC) collected from the volunteers were stimulated with soluble antigens from adult schistosomes or from schistosome eggs, and the production of the cytokines gamma interferon, tumor necrosis factor alpha, transforming growth factor ␤ (TGF-␤), interleukin-4 (IL-4), IL-10, and IL-13 was determined. Potential associations of the level of fibrosis with age, sex, intensity of infection, and cytokine production were investigated between the three groups. Univariate analysis identified associations of age (>50), gender (male), and absence of eggs/g of feces with moderate/severe fibrosis and an association of intensity of infection (>100 eggs) with incipient fibrosis. When cytokine production in PBMC cultures stimulated by soluble egg antigens was categorized as low or high, significant differences in the distribution of IL-13 levels were established between groups 0 and 2. No significant differences were detected between the groups in the cytokines produced by PBMC cultures stimulated with soluble antigens from adult schistosomes. When all variables were tested in multivariate analyses, only IL-13 was strongly associated with fibrosis (odds ratio ‫؍‬ 5.8; 95% confidence interval [CI] ‫؍‬ 1

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“…Estudos realizados com pessoas e camundongos infectados têm caracterizado a esquistossomose como uma doença predominantemente Th2, implicando a produção de citocinas advindas desse perfil como a causa da morbidade do hospedeiro (DE JESUS et al, 2004;MAGALHÃES et al, 2005). Entretanto, dados de um trabalho realizado com modelos experimentais sugerem que a resposta Th2 é importante para a sobrevivência do paciente (FALLON et al, 2000).…”

Section: A Resposta Imune Na Esquistossomoseunclassified

Fatores De Risco Relacionados À Covid-19 Em Pacientes Com Hipertensão E Diabetes Mellitus: Revisão De Literatura

Costa¹,

Figueiredo²,

Cunha³

et al. 2020

Ciências Da Saúde: Avanços Recentes E Necessidades Sociais 3

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Comparative clinical and ultrasound study of egg-negative and egg-positive individuals from Schistosoma mansoni low morbidity endemic areas, and hospitalized patients with hepatosplenic disease

Cited by 12 publications

References 12 publications

Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni

Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni

Cytokine Production Associated with Periportal Fibrosis during Chronic Schistosomiasis Mansoni in Humans

Fatores De Risco Relacionados À Covid-19 Em Pacientes Com Hipertensão E Diabetes Mellitus: Revisão De Literatura

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