Erucismo por Lonomia spp em Teresópolis, RJ, Brasil: relato de um caso provável e revisão da literatura

Corrêa, Maria Sueli; Siqueira-Batista, Rodrigo; Gomes, Andréia Patrícia; Franco-Barbosa, Adbell; Verzola, Ana Candida Arruda; Oliveira, Fabiana Ribeiro Queiroz de; Squeff, Fabiano Alves; Motta-Leal-Filho, Joaquim Maurício da; Tavares, Renato Henriques; Amorim, Daniela Silva de; De-Maria-Moreira, Nelson Luís; Santos, Sávio Silva

doi:10.1590/s0037-86822004000500011

Cited by 13 publications

(7 citation statements)

References 7 publications

(6 reference statements)

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“…Its N-terminal sequence suggests that this toxin belongs to group III PLA 2 [74] . Although intravascular hemolysis has been described in vitro, this condition is rare in humans [16,21] . Differently to what is observed in human victims [12,15,20,29] , experimentally envenomed rats develop intravascular hemolysis with hemoglobinuria but not hematuria [73] whereas in humans hematuria can be observed [10,13] .…”

Section: Platelet Aggregation Dysfunctionmentioning

confidence: 99%

“…Bleeding diathesis may occur a few hours after the accident, which consists of gengivorrhagia, ecchymosis and hematomas of variable intensity, bleeding from many sites (nose, gums, gut, genitourinary tract, and even from recent wounds), epistaxis, hematemesis or hematuria [10,13,15] . Hemolysis has been described in only two cases out of all envenomed patients in southern Brazil [16,21] . In the most severe cases, if the victim is not quickly treated, pulmonary and intracranial hemorrhages and acute renal failure frequently lead to death [12,13,20,[22][23][24] .…”

Section: Clinical Profilementioning

confidence: 99%

“…In 1989, an outbreak of accidents with hemorrhagic manifestations, occurring after the contact with caterpillars of L. obliqua , was registered in southern Brazil [12] . Since then, the number of accidents with humans has been increasing in the states of Rio Grande do Sul, Santa Catarina and Paraná [9,13,14] , and after that accidents were reported in the states of São Paulo [15] , Rio de Janeiro [16] and Minas Gerais [4] .…”

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confidence: 99%

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New Insight into the Mechanism of <i>Lonomia obliqua</i> Envenoming: Toxin Involvement and Molecular Approach

Alvarez-Flores

Zannin²,

Chudzinski-Tavassi³

2010

Pathophysiol Haemos Thromb

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Despite the nearly worldwide distribution of Lepidoptera, there are few species with clear documentation of adverse reactions in humans. Most syndromes caused by Lepidoptera are consequences of direct contact with the hairs or setae of caterpillars. In most instances, the adverse effects caused by moth and caterpillars are self-limited and the treatment is based on the removal of hairs, application of topical antipruritics and, in some cases, the use of oral antihistamines. However, in the case of envenoming by South American Lonomiaobliqua caterpillars, the antilonomic serum produced at Instituto Butantan in Brazil is the only effective treatment to re-establish the physiological coagulation parameters in poisoned patients and to abolish the complications seen in severe cases (e.g. consumptive coagulopathy, intracerebral hemorrhage, and acute renal failure). Many studies have been carried out to understand the pathophysiological mechanism of envenoming by L. obliqua. Several toxic principles were found in bristle extract and the hemolymph, probably related to the envenoming. An interesting fact is that some toxins from the venom usually have more than one function. With the advent of molecular biology techniques it has become possible to analyze these processes at a molecular level, thus giving rise to hypotheses on the molecular basis of envenomation. This review contributes to enhance our understanding of the dramatic alterations that hemorrhagic syndrome causes in patients, current treatment, and the diversity of the molecules involved in this pathology.

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Section: Platelet Aggregation Dysfunctionmentioning

confidence: 99%

Section: Clinical Profilementioning

confidence: 99%

mentioning

confidence: 99%

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New Insight into the Mechanism of <i>Lonomia obliqua</i> Envenoming: Toxin Involvement and Molecular Approach

Alvarez-Flores

Zannin²,

Chudzinski-Tavassi³

2010

Pathophysiol Haemos Thromb

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“…prevalecen en hábitats donde se encuentra el artrópodo, es decir, en áreas donde existen árboles frutales, cercanas a residencias rurales, las que pueden albergar grupos de orugas (7,8) . En Perú, las zonas de selva alta y baja, según los casos reportados, serían los hábitats más frecuentes.…”

Section: Figuraunclassified

Niña con erucismo hemorrágico por Lonomia spp. reporte de un caso

Peña-Vásquez

Vásquez-Paz

Vásquez-Becerra

et al. 2016

Rev Peru Med Exp Salud Publica

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RESUMENLos accidentes causados por las setas urticantes o venenosas de las orugas de lepidópteros, se conocen como erucismo. Estos accidentes se producen por el contacto accidental, especialmente por los niños, con las cerdas sobre el cuerpo del insecto, conectadas con glándulas venenosas. Los síntomas pueden ser locales o sistémicos, con presentaciones clínicas fatales. El accidente ocasionado por las orugas del género Lonomia spp. puede desencadenar síndromes hemorrágicos, constituyendo estos la forma más grave de erucismo. Se reporta el caso de una niña de 5 años, procedente del poblado de Villarondos, en la Amazonía del Perú, departamento de Huánuco, la cual incidentalmente se hinca con las cerdas de una oruga, cursando luego con anemia hemolítica, plaquetopenia y trastorno de la coagulación. El diagnóstico fue establecido por la anamnesis, cuadro clínico, exámenes de laboratorio y respuesta al suero antilonómico. Se discuten los aspectos clínicos, laboratoriales y terapéuticos de erucismo por Lonomia spp.Palabras clave: Erucismo, Lonomia spp, coagulación intravascular diseminada, trastorno de la coagulación (fuente: DeCS BIREME). HEMORRHAGIC ERUCISM DUE TO Lonomia spp. IN A GIRL:A CASE REPORT ABSTRACT Accidents caused by urticating or poisonous setae from lepidoptera caterpillars are known as erucism. These accidents are produced by accidental contact, especially in children, with bristles on the insect's body surface, connected to venom glands. Symptoms may be local or systemic, with deadly clinical presentations. The accident caused by Lonomia spp. caterpillars can trigger bleeding disorders, which is considered the most severe type of erucism. The case of a 5-year-old girl is reported. She was from the town of Villarondos, in the Peruvian Amazon, department of Huánuco, who accidentally knelt down on caterpillar bristles, and subsequently experienced hemolytic anemia, plateletopenia, and coagulation disorder. The diagnosis was made based on the medical history, clinical manifestation, laboratory examination results, and response to antilonomic serum. The clinical, laboratory, and therapeutic aspects of erucism due to Lonomia spp. are discussed.

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“…A case of erucism reported in Teresópolis municipality (Rio de Janeiro State), located approximately 120km from Juiz de Fora, presented symptomatology characteristic of accidents with specimens of Lonomia (Corrêa et al 2004). Although located in different states, both cities are nearby and present a very similar climate and vegetal covering.…”

mentioning

confidence: 99%

Lonomia obliqua Walker, 1855 (Lepidoptera: Saturniidae): first report in the Zona da Mata Mineira region, Southeast Brazil

Almeida¹,

Castroa²,

Bernardo³

et al. 2013

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Abstract:Lonomia accidents occur by contact to caterpillar bristles that penetrate the skin of the victim. This moth presents toxins in its larval stage, which has hemorrhagic effects that can cause accidents and even death in humans. This study presents the first report of Lonomia obliqua in the Zona da Mata Mineira, Southeast Brazil. As the species abundance and phenology are still little known in the region further studies are important, so that prevention and educational measures can be adopted.

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Erucismo por Lonomia spp em Teresópolis, RJ, Brasil: relato de um caso provável e revisão da literatura

Cited by 13 publications

References 7 publications

New Insight into the Mechanism of <i>Lonomia obliqua</i> Envenoming: Toxin Involvement and Molecular Approach

New Insight into the Mechanism of <i>Lonomia obliqua</i> Envenoming: Toxin Involvement and Molecular Approach

Niña con erucismo hemorrágico por Lonomia spp. reporte de un caso

Lonomia obliqua Walker, 1855 (Lepidoptera: Saturniidae): first report in the Zona da Mata Mineira region, Southeast Brazil

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