Chagasic enteropathy

Meneghelli, U. G.

doi:10.1590/s0037-86822004000300012

Cited by 50 publications

(39 citation statements)

References 27 publications

(24 reference statements)

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“…This denervation affects these organs' functions, and especially those of the esophagus and sigmoid colon, which require coordination to propel their contents through their distal sphincters. The climax of megaesophagus and megacolon is the decompensated stage of the disease (35) , which can be triggered by various parasite strains (36) or a cross-reaction between T. cruzi antigens and the host tissues (37) .…”

Section: Discussionmentioning

confidence: 99%

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Andrade

Câmara

Nunes

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 99%

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Andrade

Câmara

Nunes

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Degenerative changes in the intestinal wall together with a decrease in the number of nervous elements, and particularly neurons, in the region of the myenteric plexus have been confirmed. Such changes take place in the course of Chaga's disease, in which Trypanosoma cruzi parasites destroy the ENS, causing chronic constipation and leading to serious pathological widening of the large intestine [18,[20][21][22]. Taking into account the lack of nervous elements in the solid cancerous tumour destroying the wall of the intestine, as confirmed in this investigation, together with the results of investigations of other pathologies of the intestine, where destruction of the ENS leads to gradual constipation and widening of the colon, similar pathologic changes may be indicated as taking place also in the course of carcinoma of the large intestine.…”

Section: Discussionmentioning

confidence: 99%

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

Godlewski

2010

Folia Histochem Cytobiol.

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Abstract:The innervations of the large intestine is responsible for it peristalsis and contractilibility. Investigations of the enteric nervous system in many colon diseases have revealed changes in this structure. No study has been carried out on morphological changes of the enteric nervous system in the human large intestine with carcinoma. The aim of this study was to investigate potential changes in the structure of the enteric neurons in patients with sigmoid and rectal cancer. Material for the study was obtained from patients undergoing operations due to carcinoma of the sigmoid colon and rectum. Microscopic observation of the cancerous tumor of the human large intestine revealed changes in the enteric nervous system innervating this part of the gastrointestinal tract. In the region of the enteric plexuses located close to the tumour, disruption of their correct placement and structure was observed. The changes also consisted of the disappearance of neurons and nerve fibers forming these plexuses. In the solid cancerous tumour, elements of the enteric nervous system were not present. Destruction of the enteric nervous system in the course of carcinoma of the large intestine may cause disruption of proper intestinal function and may be responsible for part of symptoms which the patients suffer.

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“…The infection by the parasite causes alterations in the enteric nervous system such as megaesophagus and megacolon. There is evidence of denervation of myenteric ganglia [1][2][3][4][5] as a pathogenic mechanism of intestinal accompaniment. The best chance to avoid morbidity is the treatment of the disease at its early acute stages [6] and novel therapeutic approaches are dependent in better understanding of the complex pathogenesis of this disease.…”

Section: Introductionmentioning

confidence: 99%

“…Significant neuronal loss is necessary to the development of human chagasic megacolon [1,4], and the different classes of neurons may be more or less affected [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Nitrergic Myenteric Neurons are Spared in Experimental Chagasic Megacolon

Ricci¹,

Campos²,

Cartelle³

et al. 2016

J Neuroinfect Dis

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Chagas disease is a chronic disorder caused by the Trypanosoma cruzi protozoan. The infection causes alterations to the enteric nervous system such as megaesophagus and megacolon. There is evidence of denervation of myenteric ganglia. The intense parasitism of acute phase affects neuronal integrity but contrasts with the absence of parasites and the discreet inflammatory process of chronic phase, indicating a progressive injury mechanism that needs to be better understood in the megacolons. The potential selectivity of enteric neurons classes affected by the progression of the disease is not yet clear. Nitrergic neurons which co-localize other neurotransmitters represent the most common inhibitory neuron of the ENS. Recently a chronic stage of the Chagas disease was reproduced experimentally in a suitable murine model of megacolon. Considering the limitation of studying human intestine and the controversy on the pattern of nNOS involvement in chagasic megacolon, we decided to assess the nitrergic neurons in the myenteric plexus of mice. We used antibodies against structural protein gene product 9.5 (PGP 9.5) and functional neuronal nitric oxide synthase (n-NOS) at the acute and chronic phase of the disease to quantify myenteric ganglionar neurons in the colon of infected and non-infected mice. We found a reduction in the ganglionar number of neurons detected by anti-protein gene product 9.5 antibodies in colon from mice at the chronic stage. However, the number of nitrergic neurons per ganglia remained unchanged along the acute to phase chronic of the disease. Our findings indicate a long-term preservation of nitregic neurons detrimental to other classes of enteric in our model of experimental Chagas disease. We propose that differential loss of enteric neurons is at least one of the structural substrate for the development of the longterm morphfunctional changes that lead to the megacolon.

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Chagasic enteropathy

Cited by 50 publications

References 27 publications

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

Nitrergic Myenteric Neurons are Spared in Experimental Chagasic Megacolon

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