Malária cerebral no Ceará: relato de caso

Braga, Marcus Davis Machado; Alcântara, Geritza Chagas; Silva, Cristiane Nobre da; Nascimento, Cyntia Gioconda Honorato

doi:10.1590/s0037-86822004000100014

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…The frequency of cerebral malaria varies widely and is noted to occur in 0.01% to 16% of the patients. (35) It is relatively common in severe malaria and is the main cause of death, with a mortality rate of 10% to 50%. (36) Cerebral malaria is defined as the coma or seizures that accompany patients infected with P. falciparum who have no other cause for encephalopathy.…”

Section: Cns Involvement (Cerebral Malaria)mentioning

confidence: 99%

Malária grave por Plasmodium falciparum

Gomes¹,

Vitorino²,

Costa³

et al. 2011

Rev. bras. ter. intensiva

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Malaria is one of the world's leading parasitic diseases and affects a considerably large number of people. Considering the epidemiological reach of Plasmodium falciparum, which is almost always responsible for the most severe cases of malaria, a discussion of the clinical features and therapeutic interventions is important. In the cases of patients with severe malaria, admission to an intensive care unit is mandatory to reduce complications. To have an impact on survival rates, treatment with antimalarial drugs and supportive measures should be initiated as quickly as possible. The aim of this article is to discuss the components of severe malaria, with an emphasis on its clinical features and treatment.

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Section: Cns Involvement (Cerebral Malaria)mentioning

confidence: 99%

Malária grave por Plasmodium falciparum

Gomes¹,

Vitorino²,

Costa³

et al. 2011

Rev. bras. ter. intensiva

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Status febrilis mit Bewusstlosigkeit

et al. 2005

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Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

Lacerda

Mourão

Alexandre

et al. 2012

Malar J

135

100

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The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the Plasmodium vivax infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of P. vivax have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse P. vivax endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out.

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Malária cerebral no Ceará: relato de caso

Cited by 7 publications

References 2 publications

Malária grave por Plasmodium falciparum

Malária grave por Plasmodium falciparum

Status febrilis mit Bewusstlosigkeit

Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

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