Epidemiologia das infecções hematogênicas por Candida spp

Abstract

Candida spp is associated to almost 80% of all nosocomial fungal infections and is considered a major cause of blood stream infections. Candida spp is the fourth most common cause of blood stream infections in the United States, where this agent is responsible for 8% of all invasive infections documented in this site. At the present, non-albicans species are related to at least 50% of all invasive infections due to Candida spp and they present differences in terms of clinical outcome as well as susceptibility to antifungal drugs. The crude mortality rate of candidemia is between 40 and 60% which makes this infection an important challenge for all clinicians from tertiary care hospitals of diverse different countries.

Bacterial and fungal colonization of burn wounds

“…Colonization of the burn wound with fungi is not a surprising phenomenon in view of the changes in microbial flora induced by systemic and topical chemotherapy. The origin of the fungi in these patients does not appear to be the gastrointestinal tract as suggested in other studies of diseases complicated by fungemia (Colombo & Guimarães 2003). An epidemiological study demonstrated recovery of Candida from the wounds of 8 to 10% of severely burned patients studied and the absence of fungi in the stool or nasofharynx of these patients (Bruck et al 1972).…”

Fungal agents in different anatomical sites in Public Health Services in Cuiabá, state of Mato Grosso, Brazil

“…According to CROCCO et al 13 , candidiasis expresses the variety of relations that occur between the host and autochthon microbiota, ranging from commensalism to systemic disease. Different groups of previously used medications can contribute to the appearance of superficial and systemic fungal infections by yeasts of the genus Candida 11 . In this study, antifungal drugs were reported by 12.6% of patients, followed by corticosteroids (4.5%) and antibiotics (3.5%).…”

Thyroid abnormalities in term infants with fungal sepsis

“…13 Any variable that causes an imbalance in the microbiota or harm to the gastrointestinal mucosa can be a facilitating agent for the translocation of Candida ssp. from the intestinal lumen to the mesenteric capillaries.…”

“…14 The second most common cause of bloodstream infection in pediatric and neonatal patients admitted to intensive care units in the USA, Europe, and Latin America is fungal infections, especially by Candida spp. [13][14][15][16] In recent years, an increase in infections caused by other species of Candida non-albicans, such as Candida tropicalis, Candida glabrata, Candida krusei, Candida lusitaniae and Candida guilliermondii, has been noted. Multicenter studies conducted in Brazil have also confirmed the prevalence of species of Candida albicans and non-albicans (C. tropicalis and parapsilosis).…”