Hanseníase no Brasil

Araújo, Marcelo Grossi

doi:10.1590/s0037-86822003000300010

Cited by 144 publications

(172 citation statements)

References 3 publications

(1 reference statement)

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“…Regarding the forms of the disease, only 3 patients (8%) were Indeterminate, considered as clinical manifestation of the disease (9) whereas the majority, 34 patients (92%) presented borderline, pointing out for a later diagnoses.…”

Section: Discussionmentioning

confidence: 95%

Socioeconomic and demographic profile of leprosy carriers attended in nursing consultations

Duarte¹,

Ayres

Simonetti

2007

Rev. Latino-Am. Enfermagem

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Section: Discussionmentioning

confidence: 95%

Socioeconomic and demographic profile of leprosy carriers attended in nursing consultations

Duarte¹,

Ayres

Simonetti

2007

Rev. Latino-Am. Enfermagem

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“…Se a baciloscopia fosse o único critério para a classificação dos pacientes, 20% dos casos MBs seriam considerados como PBs, segundo os autores Andrade e et al (21) . A baciloscopia mostra-se negativa (IB=0) nas formas tuberculóide e indeterminada, fortemente positiva na forma virchowiana e revela resultado variável na forma dimorfa (22) .…”

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Deteccção do DNA de Mycobacterium leprae em secreção nasal

et al. 2008

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ABSTRACT ABSTRACT ABSTRACT Studies have demonstrated high sensibility of the polimerase chain reaction (PCR) technique in the identification of the Mycobacterium leprae DNA . This study aimed to evalue the PCR sensibility at the detection of the M. leprae DNA in nasal swab of leprosy patients and to compare the results with the bacilloscopy and multibacillary (MBs) and paucibacilares (PBs) forms. Nasal secretion samples of 24 leprosy patients were collected, and were preserved in one and two lise's solution. The PCR results were highly significant (p <0.0000) and they revealed grater sensibility than bacilloscopy, in several clinical forms. Nevertheless, still different studies are necessary, testing new markers and preservatives, with the purpose of lifting up the sensibility of this technique, in nasal secretion samples. Descriptors: Descriptors: Descriptors: Descriptors: Descriptors: Leprosy; Mycobacterium leprae; Polymerase Chain Reaction; Nursing research. RESUMEN RESUMEN RESUMEN RESUMEN RESUMENLos estudios han demostrado una alta sensibilidad de la técnica de Reacción en Cadena de la Polimerasa (PCR) para identificar el ADN de Mycobacterium leprae. El objetivo del estudio fue evaluar la sensibilidad de la PCR en la detección de ADN de M. leprae en hisopo nasal de los pacientes hansenianos y comparar los resultados con la baciloscopía y las formas multibacilares (MBs) y paucibacilares (PBS). Se obtuvieron muestras de secreción nasal de 24 pacientes hansenianos, conservados en solución de lisis uno y dos. Los resultados de la PCR fueron muy significativas (p <0.0000) y mostró una mayor sensibilidad que la baciloscopía, en diferentes formas clínicas. Sin embargo, otros estudios son aún necesarios, el ensayo de nuevos marcadores y conservantes con el fin de aumentar la sensibilidad de esta técnica, en muestras de secreción nasal. Descriptores: Descriptores: Descriptores: Descriptores: Descriptores: Lepra; Mycobacterium leprae; Reacción en cadena de la polimerase; PInvestigación en enfermería.Deteccção do DNA de Deteccção do DNA de Deteccção do DNA de Deteccção do DNA de Deteccção do DNA de Mycobacterium leprae Mycobacterium leprae Mycobacterium leprae Mycobacterium leprae Mycobacterium leprae em secreção nasal em secreção nasal em secreção nasal em secreção nasal em secreção nasal 7 3 5 7 3 5 7 3 5 7 3 5 7 3 INTRODUÇÃO INTRODUÇÃO INTRODUÇÃO INTRODUÇÃO INTRODUÇÃOA hanseníase é uma doença infecciosa crônica, causada pelo Mycobacterium leprae, que afeta predominantemente a pele, nervos periféricos e membranas mucosas, com alta prevalência no mundo, constituindo uma das endemias de prioridade pela Organização Mundial da Saúde (OMS) pelo seu poder incapacitante, que marginaliza e interrompe a capacidade produtiva de milhares de pacientes (1) .O homem é considerado como a única fonte de infecção. E o principal meio de transmissão da doença é provavelmente pela propagação de aerossol de secreções nasais e gotículas do trato respiratório de pacientes não tratados, embora possa ocorrer pelo contato co...

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“…These forms range from tuberculoid, with a predominantly cellular immune response, to lepromatous leprosy dominated by a humoral response 4,11 . These responses are associated with specific mechanisms for the recognition of antigens, mediated by receptors present on the membranes of T and B lymphocytes 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

Rodrigues

Ribeiro

Berber³

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. Methods: Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. Results: The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%). Conclusions: The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals.

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Hanseníase no Brasil

Cited by 144 publications

References 3 publications

Socioeconomic and demographic profile of leprosy carriers attended in nursing consultations

Socioeconomic and demographic profile of leprosy carriers attended in nursing consultations

Deteccção do DNA de Mycobacterium leprae em secreção nasal

Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy

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