Inquérito soroepidemiológico para infecções por fungos causadores de micoses sistêmicas na Reserva Indígena Xacriabá, Estado de Minas Gerais

Abstract

Xacriabá Indian Reserve is situated in the north of Minas Gerais State, Brazil, near the municipality of Manga and São Francisco River. The Indian population is miscegenated with caucasian and negroid people and have farming activities. Blood samples were collected from 180 inhabitants of the reserve (85 men and 95 women), 15 to 84 years old. Serum antibodies against antigens of Paracoccidioides brasiliensis, Histoplasma capsulatum, Cryptococcus neoformans, and Candida albicans were tested for by counterimmunoelectrophoresis method. Seropositivity was verified in 5%, 3.9%, 4.2%, and 6.7%, respectively of the 180 samples. Those seropositive for antigens of P. brasiliensis and H. capsulatum were predominantly women and had lower age and more elevated mean titers of antibodies than individuals whose sera reacted with antigens of C. neoformans and C. albicans. The results suggest the occurrence of paracoccidioidomycosis-infection and histoplasmosis-infection in the Xacriabá Indian Reserve, particularly in the first decades of life of the inhabitants.

An update on the occurrence of Paracoccidioides species in the Midwest region, Brazil: Molecular epidemiology, clinical aspects and serological profile of patients from Mato Grosso do Sul State

“…Four were born in different regions of Brazil (Northeast, South and Southeast), and currently are living in the state of Mato Grosso do Sul. For instance, one patient was born in the state of Ceará, where PCM is rare [38], and another one in Minas Gerais, an important endemic area [39,40]; both patients were infected by P. brasiliensis sensu stricto (S1). In addition, two patients were born in the state of Paraná-one infected by P. restrepiensis (PS3) and another by P. brasiliensis sensu stricto (S1), respectively rare and common genotypes in this Brazilian region.…”

New Trends in Paracoccidioidomycosis Epidemiology

“…In Brazil, anti- Paracoccidioides spp. antibodies have been detected in 27% of blood donors in the state of Paraná and in 5% of Indians in the state of Minas Gerais [ 64 , 65 ]. These studies suggest previous asymptomatic infection with this fungus, but may also be limited by possible cross-reactivity with other agents of fungal infection.…”

Epidemiology of Paracoccidioidomycosis

“…In an indigenous area in the North of the Minas Gerais State , 5% and 3.9% of the 180 inhabitants had a positive serological test to P. brasiliensis and H. capsulatum , respectively. Higher antibody titers were detected in young adults, suggesting that the infection occurs early in life 63 . Among those with paracoccidioidomycosis-infection, anti- P. brasiliensis antibody titers are barely increased and may be detected only over a short period of time.…”