2002
DOI: 10.1590/s0037-86822002000200001
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Abstract: Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Lei… Show more

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Cited by 12 publications
(9 citation statements)
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“…Previous data from our laboratory [11] and from others [12] showed that vaccination of wild-type mice with a crude extract of L. amazonensis, in the presence of Corynebacterium parvum as an adjuvant, confers IFN-g-dependent protection against infection, as measured by the parasite burden and the size of lesions. Surprisingly, our data also showed that the absence of IL-12 did not prevent the vaccination protocol from protecting mice, as determined in mice deficient in the p40 chain of IL-12 and IL-23 by homologous recombination (IL-12/23p40 À/À ).…”
Section: Introductionmentioning
confidence: 84%
“…Previous data from our laboratory [11] and from others [12] showed that vaccination of wild-type mice with a crude extract of L. amazonensis, in the presence of Corynebacterium parvum as an adjuvant, confers IFN-g-dependent protection against infection, as measured by the parasite burden and the size of lesions. Surprisingly, our data also showed that the absence of IL-12 did not prevent the vaccination protocol from protecting mice, as determined in mice deficient in the p40 chain of IL-12 and IL-23 by homologous recombination (IL-12/23p40 À/À ).…”
Section: Introductionmentioning
confidence: 84%
“…As vacinas de 2ª geração induzem uma resposta imunológica característica, com aumento nos níveis de INF-γ e NO. Vale ressaltar que as vacinas de 1ª e 2ª gerações estimulam a fagocitose e a ativação de células T CD8+ e são capazes de desencadear resposta imune protetora, quando os animais são desfiados experimentalmente com diversas espécies do parasito Leishmania, causadores das formas tegumentar e visceral da infecção (Mayrink et al, 2002;Araújo et al, 2011).…”
Section: Antígenos Vacinais: Citocinas E Imunoglobulinas Específicasunclassified
“…When LaAg, which is composed of antigens from whole L. amazonensis promastigotes, was associated to Corynebacterium parvum and used for immunization, induced protection against L. amazonensis infection in C57Bl10 mice [30].…”
Section: Whole L Amazonensis Antigens From Promastigotes (Laag) and mentioning
confidence: 99%