Papilomavírus humano associado a lesões de cérvice uterina

Noronha, Vânia Lúcia; Mello, Wyller Alencar de; Villa, Luisa L.; Brito, Arival Cardoso de; Macedo, R Oliveira; Bisi, Fátima; Mota, Rosilda; Sassamoto, Kyio; Monteiro, Talita Antônia Furtado; Linhares, Alexandre da Costa

doi:10.1590/s0037-86821999000300003

Cited by 35 publications

(33 citation statements)

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“…The mean age of the patients with cervical cancer was 47.3 years old, similar to that reported in a multicentric study covering countries on four continents (47.8%), but above the mean age described for African countries (33.9 years old) (22) and below the means described in São Paulo (southeastern Brazil, 52 years old), Belém (northern Brazil, 51 years old), and Goiânia (Central Brazil, 49 years old) (1,23,24). The mean age found in this study was also below the mean age reported in a multicentric study covering 9 developing countries, including Brazil, whose mean age was 49 years (25).…”

Section: Discussionsupporting

confidence: 83%

Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil

et al. 2011

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Abstract. This study analyzed the prevalence of human papillomavirus (HPV) in cervical specimens obtained from women with normal cytology and with cervical cancer, in order to evaluate their correlation with health status and demographic characteristics, as well as sexual and reproductive activity in women treated at a cancer reference hospital in Natal, Northeast Brazil. A total of 158 women were divided into 2 groups according to their health status: group I comprised 110 women with normal cytology, and group II comprised 48 women with cervical cancer. Cervical smears were analyzed by cytological or histopathological examination for the detection of cytological alterations, and by PCR for HPV DNA detection using MY09/11 primers, followed by HPV genotyping by dot blot hybridization. Results showed overall HPV prevalence to be 24.5% in group I, with 19.1% of patients having single infection and 5.4% double infection. The HPV prevalence in group II was 85.4%, with 79.2% of patients having single and 6.2% double infection. We identified 10 different HPV genotypes, most with high oncogenic potential. HPV 16 was the most prevalent genotype in the two studied groups, followed by HPV 58 and HPV 18. High-risk HPV genital infection, chronological age, ethnicity, early onset of sexual and reproductive activities, multiple sexual partners and smoking increased the risk for cervical cancer.

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Section: Discussionsupporting

confidence: 83%

Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil

et al. 2011

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“…Several studies investigated HPV genotypes contribution among ICC cases of the Brazilian population. All them reported HPV16 and 18 as the most frequent HPV types [13-16], followed by HPV 31 and 33 [13,14], with exception of the Northeast region, where the third most common HPV type is HPV58, followed by HPV45 [16]. …”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil

et al. 2013

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BackgroundInvasive cervical cancer is the second most common malignant tumor affecting Brazilian women. Knowledge on Human Papillomavirus (HPV) genotypes in invasive cervical cancer cases is crucial to guide the introduction and further evaluate the impact of new preventive strategies based on HPV. We aimed to provide updated comprehensive data about the HPV types’ distribution in patients with invasive cervical cancer.MethodsFresh tumor tissue samples of histologically confirmed invasive cervical cancer were collected from 175 women attending two cancer reference hospitals from São Paulo State: ICESP and Hospital de Câncer de Barretos. HPV detection and genotyping were performed by the Linear Array HPV Genotyping Test (Roche Molecular Diagnostics, Pleasanton,USA).Results170 out of 172 valid samples (99%) were HPV DNA positive. The most frequent types were HPV16 (77.6%), HPV18 (12.3%), HPV31 (8.8%), HPV33 (7.1%) and HPV35 (5.9%). Most infections (75%) were caused by individual HPV types. Women with adenocarcinoma were not younger than those with squamous cell carcinoma, as well, as women infected with HPV33 were older than those infected by other HPV types. Some differences between results obtained in the two hospitals were observed: higher overall prevalence of HPV16, absence of single infection by HPV31 and HPV45 was verified in HC-Barretos in comparison to ICESP patients.ConclusionsTo our knowledge, this is one of the largest studies made with fresh tumor tissues of invasive cervical cancer cases in Brazil. This study depicted a distinct HPV genotype distribution between two centers that may reflect the local epidemiology of HPV transmission among these populations. Due to the impact of these findings on cervical cancer preventive strategies, extension of this investigation to routine screening populations is warranted.

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“…Corroborando com esses achados, Câmara et al 20 , em Brasília, e De Luca et al 21 25 encontraram HPV de tipo 16 em 60,4% das mulheres com câncer cervical, em hospital de referência, em Belém/PA, utilizando técnica de PCR em material colhido por biópsia dirigida por colposcopia. Convém observar que esses autores estudaram a frequência de HPV 16 em grupos de mulheres com lesões mais graves, enquanto o trabalho ora apresentado considera todas as anormalidades citopatológicas, na sua análise, das quais somente 12 se apresentavam com HSIL ou lesão maior.…”

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PaPilomavírus Humano (HPv) em mulHeres submetidas a rastreamento Para CânCer de CérviCe uterina, belém – Pará – brasil

Noronha¹

2011

J Bras Doenças Sex Transm

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Introduction: human papillomavirus (HPV) is the agent of cervical uterine cancer. Objective: determine the prevalence of genital infection due to HPV and their correlation with results in the oncotic cytology. Methods: in a cross-sectional study, 1021 women, age 30 to 45 years were enrolled and submitted to cervical cancer screening. All patients answered a standard protocol. Samples of the uterine cervix were sent to citopathological analysis and to identification of HPV. Results: prevalence of HPV was 12.4%; in women with normal cervical cytology the prevalence of HPV was 8,7% compared to 43,4% in women with altered cervical cytology (28.9% among women with ASCUS/AGUS; 60.0% among women with LSIL; 90.0% among women with HSIL and 100.0% both in women with invasive carcinoma and in situ adenocarcinoma). Chance of detection of HSIL was 94 times higher in women who had HPV in the uterine cervix. A separate analysis including only the 116 HPV infected women revealed that HPV oncogenic types corresponded to 79.3% of the cases (71.8% in women with negative cervical cytology and 91.1% in women with altered cervical cytology). The frequency of oncogenic HPV types in 116 women infected with HPV was 79.3% [71.8% in women with negative citology and 91.1% in women with abnormalities in the citology exam). The odds to detect abnormalities in the citopatology exam was four times greater in the presence of HPV of high risk. HPV 16 was the most frequent type observed (24.4% of women with abnormal cytology and in 7,0% of those with negative cytology). Multiinfection was detected in 5.7% of women with abnormal cytology and in 1.1% with negative cytology. Conclusion: in this study, HPV infection and abnormal cytological findings in the uterine cervix were frequently observed and there was an association between them.

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Papilomavírus humano associado a lesões de cérvice uterina

Abstract: Resumo Estudou-se a prevalência do papilomavírus humano (HPV)

Cited by 35 publications

References 18 publications

Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil

Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil

Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil

PaPilomavírus Humano (HPv) em mulHeres submetidas a rastreamento Para CânCer de CérviCe uterina, belém – Pará – brasil

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