Zigomicose nasofacial no Estado do Pará: registro de dois casos

Moraes, Mário Augusto Pinto de; Arnaud, M; Almeida, Margarida Maria Roque

doi:10.1590/s0037-86821997000400009

Cited by 8 publications

(8 citation statements)

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“…Amphotericin B remains the only clinically effective antifungal drug even though its in vitro susceptibility data are usually more promising than clinical outcomes [1]. Our in vitro antifungal susceptibility testing showed a good activity of amphotericin B and was in agreement with our previous findings on the in vitro effect of azole antimycotics on A. corymbifera (Table 1) [6,7].Although Mucorales are generally considered as fungi primarily resistant to azole antimycotics, some in vitro susceptibility data and several reports have suggested that azole derivatives such as fluconazole [8][9][10][11][12][13], ketoconazole [14][15][16] and itraconazole [13,17,18] may be of some benefit in the treatment of mucormycosis, particularly caused by Absidia.There could be several causes of this controversy, such as the lack of an adequate antifungal susceptibility system for mucoraceous molds or the immunological status of host. Some of these case reports do not give the precise description of all predisposing factors and their changes in the course of the infection and thus some improvements or cures could result from the reconstruction of anti-infective mechanisms of host immunity.…”

Section: Disc Diffusion Test E (Inhibition Zone In Mm)supporting

confidence: 88%

Primary Cutaneous Absidia corymbifera Infection in a Premature Newborn

et al. 2003

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Section: Disc Diffusion Test E (Inhibition Zone In Mm)supporting

confidence: 88%

Primary Cutaneous Absidia corymbifera Infection in a Premature Newborn

et al. 2003

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“…Many antifungal drugs, such as potassium iodide, amphotericin B, imidazole derivatives (fluconazole, ketoconazole, and itraconazole), or a combination of two of these drugs, 2,4,[7][8][9][10][11][12]16 have been used for the treatment of rinoentomophthoramycoses. In the present case, a good response was obtained after surgery and subsequent treatment with potassium iodide.…”

Section: Discussionmentioning

confidence: 99%

“…1 Approximately 35 cases of rhinoentomophthoramycosis have been reported in Brazil. [2][3][4][5][6][7][8][9][10][11][12] The disease begins as a tumefaction of the mucosa of the inferior turbinate that spreads to other parts of the nasal cavity, paranasal sinuses, and subcutaneous tissue of the nose and surrounding areas. The infection initially appears as a nasal obstruction followed by diffuse erythema and thickening of the skin of the nose.…”

Section: Introductionmentioning

confidence: 99%

Mucocutaneous Entomophthoramycosis Acquired by Conjunctival Inoculation of the Fungus

Bittencourt

Marback

Nossa

2006

The American Journal of Tropical Medicine and Hygiene

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Entomophthoramycoses are classified into subcutaneous, mucocutaneous, and primary visceral forms. The mucocutaneous form, also known as rhinoentomophthoramycosis, involves the mucosa and subcutaneous tissues of the nose and is caused by Conidiobolus coronatus (Entomophthora coronata). In this report, we describe the first case of mucocutaneous entomophthoramycosis acquired by introduction of the fungus through the conjunctival mucosa as a consequence of trauma involving contamination with soil. The patient was a 37-year-old man with no other complaints. The lesion was tumoral and extended into the ethmoidal and maxillary sinuses. The histopathologic appearance of the lesion was characteristic of this infection with a granulomatous process rich in eosinophils and with hyphae surrounded by an eosinophilic, periodic acid-Schiff stain-positive halo (Splendore-Hoeppli phenomenon). To the best of our knowledge, this case constitutes the first report of mucocutaneous entomophthoramycosis acquired by ocular contamination.

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“…En pacientes diabéticos y en personas con inmunosupresión existe predisposición a la enfermedad, que se puede diseminar y ser fatal (21)(22)(23). En el manejo de la enfermedad se han empleado diversos agentes con resultados satisfactorios, entre ellos, yoduro de potasio, sulfas, ketoconazol, fluconazol e itraconazol (1,(9)(10)(11)(12)14,19,24).…”

Section: Discussionunclassified

Conidiobolomicosis: hallazgos histopatológicos.

Pérez

Correa²,

Fuentes³

et al. 2004

biomedica

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La conidiobolomicosis es una micosis subcutánea que se localiza generalmente en la línea media facial; es causada por un hongo saprófito de suelos y vegetales secos, propio de regiones intertropicales, que afecta principalmente a hombres adultos. El agente etiológico Conidiobolus coronatus pertenece a la clase de los Zigomicetos, orden Entomoftorales; se caracteriza por hifas cortas y gruesas, generalmente aseptadas, que crece entre 30°C y 37°C y produce granulomas nasales. Se informan a continuación los hallazgos histológicos de un caso de conidiobolomicosis en un paciente de 31 años de raza negra, natural y procedente de la región de Urabá, quien presentaba deformidad mediofacial con edema de nariz, labio superior e imágenes polipoides en senos maxilares con destrucción del tabique nasal. La biopsia demostró inflamación granulomatosa necrosante difusa en la dermis profunda e hipodermis asociada con eosinófilos y fenómeno de Splendore-Hoeppli, en cuya zona central se ubicaban espacios aparentemente vacíos que contenían el hongo que no se tiñó con HE, pero que sí lo hizo con las coloraciones de PAS y Grocott lo cual permitió la observación de hifas de paredes gruesas y rígidas, con torsión central y extremos cónicos.Palabras clave: conidiobolomicosis, Conidiobolus coronatus, micosis subcutáneas, entomoftoromicosis, rinoentomoftoromicosis, cigomicosis. Conidiobolomycosis: a case report with histophathologic findingsConidiobolomycosis is a subcutaneous mycosis of the facial midline affecting primarily adult males. It is caused by the saprophytic fungus, Conodiobolus coronatus, present in soils and dried vegetables, characteristic of intertropical regions. C. coronatus belongs to the class Zygomycetes, order Entomophthorales; it is a fungus composed of thick, short hyphae that grows at temperatures between 30°C and 37°C and causes nasal granulomas. The histologic findings are described of a case of conidiobolomycosis in a 31-year-old male, born and resident in the Urabá region of Colombia. He presented with a mid-facial deformity of the nose and upper lip edema, and polypoid images in the maxillary sinuses with destruction of the nasal septum. The biopsy revealed a diffuse inflammatory lesion located in the deep dermis and in the hypodermis corresponding to a necrotizing granuloma. Associated eosinophils and the presence of the Splendore-Hoeppli phenomenon were noted in the vacant central zone which apparently corresponded to location of the fungal hyphae. They did not stain with HE stain, but reacted to the PAS and Grocott staining techniques and appeared as rigid, thick-walled hyphae, centrally twisted and with cone-shaped endings.

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Zigomicose nasofacial no Estado do Pará: registro de dois casos

Cited by 8 publications

References 1 publication

Primary Cutaneous Absidia corymbifera Infection in a Premature Newborn

Primary Cutaneous Absidia corymbifera Infection in a Premature Newborn

Mucocutaneous Entomophthoramycosis Acquired by Conjunctival Inoculation of the Fungus

Conidiobolomicosis: hallazgos histopatológicos.

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