Estudo dos neurônios do plexo cardíaco na infecção aguda pelo Trypanosoma cruzi em ratos albinos

Chapadeiro, E; Beraldo, Paulo Sérgio Siebra; Jesus, Paulo César de; Fernandes, Patrícia Dias; Júnior, Luiz Fernando Junqueira

doi:10.1590/s0037-86821994000200004

Rev. Soc. Bras. Med. Trop.

1994

DOI: 10.1590/s0037-86821994000200004

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Estudo dos neurônios do plexo cardíaco na infecção aguda pelo Trypanosoma cruzi em ratos albinos

E Chapadeiro¹,

Paulo Sérgio Siebra Beraldo²,

Paulo César de Jesus³

et al.

Abstract: O estudo histológico do plexo nervoso autonômico do coração de ratos albinos, na fase aguda da infecção pelo Trypanosoma cruzi, mostrou ganglionite, periganglionite e neurite de intensidades variáveis. Entretanto, a contagem dos neurônios dos gânglios não revelou redução (denervação) significativa dos mesmos.

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Cardiac denervation in mice infected withTrypanosoma cruzi

Rodrigues

Liberti²,

Maifrino³

et al. 2002

Annals of Tropical Medicine & Parasitology

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The neuronal features of the hearts of mice that were acutely or chronically infected with the Y strain of Trypanosoma cruzi were compared with those of control hearts from uninfected mice. Whole-mount preparations of the murine atria, isolated by microdissection, were stained to reveal neurons with NADH-diaphorase activity. Counts, by a microscopist who was blind to the infection status of the donor mouse, revealed that there were significantly (38%) fewer such neurons in the atria from the acutely infected mice than in the atria from the control hearts. The ganglia of the infected mice were also irregularly distributed, severely damaged ganglia being found beside slightly degenerated or morphologically normal ones. Although the ganglia contained small, medium and large neurons, the apparent destruction caused by T. cruzi was confined to the large ones. As neuron counts in preparations of hearts from mice with chronic infections were 32% lower than those in the control hearts, there appears to be no additional loss of cardiac neurons as the acute infection in mice progresses to the chronic phase.

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Cardiac denervation in mice infected withTrypanosoma cruzi

Rodrigues

Liberti²,

Maifrino³

et al. 2002

Annals of Tropical Medicine & Parasitology

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show abstract

Despopulação neuronal cardíaca em hamsters (Mesocricetus auratus) cronicamente infectados com o Trypanosoma cruzi

Chapadeiro

Silva

et al. 1999

Rev. Soc. Bras. Med. Trop.

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The aim of this study was to obtain an experimental animal model of destruction of cardiac neurons in order to investigate the behavior of the cardiac nervous system of hamsters chronically infected with Trypanosoma cruzi. We counted the neuronal cells of the cardiac autonomic nervous plexus in hamsters inoculated with 35,000 blood forms of three different T. cruzi strains and killed 5, 8 and 10 months after infection. We showed for the first time severe neuronal destruction in an experimental animal model with characteristics similar to those observed in human Chagas'disease.

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Estudo dos neurônios do plexo cardíaco na infecção aguda pelo Trypanosoma cruzi em ratos albinos

Cited by 2 publications

References 4 publications

Cardiac denervation in mice infected withTrypanosoma cruzi

Cardiac denervation in mice infected withTrypanosoma cruzi

Despopulação neuronal cardíaca em hamsters (Mesocricetus auratus) cronicamente infectados com o Trypanosoma cruzi

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